{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:31:35Z","timestamp":1772897495925,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T00:00:00Z","timestamp":1129852800000},"content-version":"vor","delay-in-days":4798,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Soluble interleukin\u20102 receptors (sIL2R) in plasma have been identified as a marker of lymphocyte activation. Lymphocyte activation as a manifestation of inflammation may be important in the pathogenesis of bronchopulmonary dysplasia (BPD). To test the hypothesis that infants with BPD have higher slL2R levels, 12 infants with or at risk of developing BPD (GA \u00b1 SD, 27 \u00b1 5 weeks; BW \u00b1 SD 1,053 \u00b1 733 g) had plasma slL2R levels determined and were compared to 20 infants being ventilated for respiratory distress syndrome (RDS) (GA 2 SD, 28 \u00b1 3.5 weeks; BW \u00b1 SD, 1,133 \u00b1 390 g: P=NS for both GA and BW, t test). Tracheal aspirates in both groups were also analyzed for slL2R levels. To control for the effects of postnatal age (PNA) and study weight (SW) on the slL2R levels, another group of 16 nonventilated babies (NVB) had plasma analyzed for slL2R (PNA t SD: 39 \u00b1 40 days NVB vs. 48 \u00b1 36 days BPD; P =NS); (SW \u00b1 SD: 1391 \u00b1 250 g NVB vs. 1212 \u00b1 700 g BPD; P =NS). The following data were obtained for the plasma slL2R levels (mean 2 SEM U\/mL): RDS controls, 1,231 \u00b1 80; BPD infants, 1,790 \u00b1 120; NVB controls, 1,319 \u00b1 76; P =0.0005 RDS vs. BPD and P =0.002 BPD vs. NVB. There was no significant difference in the sIL2R levels for the infants at risk of developing BPD vs. the infants with established BPD. Also, when analyzed separately, infants at risk of BPD and the infants with established BPD had higher slL2R levels than the RDS and NVB controls. No differences were noted in the tracheal slL2R levels in the BPD vs. RDS groups. These data indicate that infants with BPD had significantly higher slL2R levels in plasma than either RDS or NVB controls. Therefore, lymphocyte activation may play a role in the pathogenesis of BPD. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1950140111","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T17:56:12Z","timestamp":1173203772000},"page":"58-62","source":"Crossref","is-referenced-by-count":11,"title":["Soluble interleukin\u20102 receptor levels in infants with bronchopulmonary dysplasia"],"prefix":"10.1002","volume":"14","author":[{"given":"John L.","family":"Stefano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Spear","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen A.","family":"Pearlman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Fawcett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Proujansky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.5.1455"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6427923"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.4049\/jimmunol.135.5.3172","article-title":"Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro","volume":"135","author":"Rubin LA","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.160.5.1450"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.6.1895"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.4049\/jimmunol.137.12.3841","article-title":"The released interleukin\u20132 receptor binds interleukin 2 efficiently","volume":"137","author":"Rubin LA","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(87)90824-3"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(88)91255-8"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198906223202506"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(87)90095-X"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81610-5"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330909"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1982.tb00643.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310704"},{"key":"e_1_2_1_16_2","first-page":"109","article-title":"The demonstration of an interleukin\u20132 like activity in the synovial fluids of rheumatoid arthntis patients","volume":"10","author":"Wilkins JA","year":"1983","journal-title":"J Rheum"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330814"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310605"},{"issue":"4","key":"e_1_2_1_19_2","first-page":"S31","article-title":"Cytokines and interleukin\u20102 receptors in polymyositis","volume":"34","author":"Wolf RE","year":"1989","journal-title":"Arth Rheum"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330310"},{"key":"e_1_2_1_21_2","first-page":"639","article-title":"T\u2010cell activation in Crohn's disease: Increased levels of soluble interleukin\u20102 receptor in serum and supematants of stimulated peripheral blood mononuclear cells","volume":"96","author":"Knoflach MP","year":"1990","journal-title":"Gastroenterology"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","unstructured":"ProujanskyR CarpenterAB. 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