{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:50:15Z","timestamp":1774565415447,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T00:00:00Z","timestamp":1129852800000},"content-version":"vor","delay-in-days":4617,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1993,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Compensatory lung growth after pneumonectomy is a well established phenomenon in young humans and experimental animals. To date, the cellular initiating and\/or regulatory factor(s) responsible for this growth response have yet to be established. We have studied changes in lung content and activity of calmodulin, a calcium\u2010dependent regulatory protein in relation with lung mass and DNA content during postpneumonectomy compensatory lung growth in 4\u2010week\u2010old rats. We observed that after left pneumonectomy, right lung calmodulin content (measured by radioimmunoassay) and calmodulin activity (measured by cyclic nucleotide phosphodiesterase activation) were increased at days 1 and 2 after surgery in the pneumonectomized rats, preceding the increase of lung mass and DNA content which started at day 3. Treatment of the pneurnonectomized rats with a highly specific calmodulin antagonist, trifluoperazine, immediately after the surgery, resulted in diminished lung calmodulin activity, sparing the calmodulin content, and in concomitant reduction of lung mass and DNA content to values intermediate between those of controls and the pneumonectomized animals. Based on these findings, we conclude that calmodulin may be an important intracellular (possibly, autocrine) initiatory or facilitatory factor in compensatory hyperplastic lung growth after pneumonectomy. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1950150304","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T18:31:11Z","timestamp":1173205871000},"page":"145-150","source":"Crossref","is-referenced-by-count":16,"title":["Role of calmodulin as an endogenous initiatory factor in compensatory lung growth after pneumonectomy"],"prefix":"10.1002","volume":"15","author":[{"given":"Anwuli F.","family":"Ofulue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Thurlbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)42588-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109965"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1985.248.2.E162"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/01902148809115122"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/138.5.1314"},{"key":"e_1_2_1_7_2","first-page":"307","article-title":"Deoxyribonucleic acid synthesis in lung cells during compensatory lung growth after pneumonectomy","volume":"117","author":"Brody JS","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1980.tb04514.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2000475"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(79)90623-5"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6243188"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(80)90849-9"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(81)80480-2"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(81)81229-X"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(82)90658-1"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950100110"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1980.tb29621.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(65)90020-5"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0620315"},{"key":"e_1_2_1_20_2","first-page":"187","article-title":"Preparation and assay of the Ca2+\u2010dependent modulator protein","volume":"10","author":"Sharma RK","year":"1979","journal-title":"Adv Cyclic Nucleotide Res"},{"key":"e_1_2_1_21_2","volume-title":"Biostatistical Analysis","author":"Zar JH","year":"1974"},{"key":"e_1_2_1_22_2","first-page":"318","article-title":"Absorption, distribution and excretion of trifluoperazine in rats","volume":"215","author":"West NR","year":"1975","journal-title":"Arch Int Pharmacodyn"},{"key":"e_1_2_1_23_2","first-page":"104","article-title":"Metabolism and disposition of trifluoperazine in the rat. II. Kinetics after oral and intravenous administration in acutely and chronically treated animals","volume":"5","author":"Schamlzing G","year":"1977","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_1_24_2","first-page":"475","article-title":"Effect of trifluoperazine on DNA synthesis during liver regeneration","volume":"18","author":"Soriano M","year":"1985","journal-title":"Cell Tissue Kinet"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(87)90515-2"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800751205"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(84)80585-2"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1986.250.4.E435"},{"key":"e_1_2_1_29_2","first-page":"G342","article-title":"Polyamine\u2010dependent growth and calmodulin\u2010regulated induction of ornithine decarboxylase","volume":"256","author":"Ginty DD","year":"1989","journal-title":"Am J Physiol"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/01902149209031694"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02719305"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.1950150304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.1950150304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T06:23:54Z","timestamp":1698215034000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.1950150304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,3]]}},"alternative-id":["10.1002\/ppul.1950150304"],"URL":"https:\/\/doi.org\/10.1002\/ppul.1950150304","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,3]]}}}