{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T00:35:44Z","timestamp":1746318944155},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T00:00:00Z","timestamp":1129852800000},"content-version":"vor","delay-in-days":4433,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In recent years flexible fiberoptic bronchoscopy (FFB) has been applied to children for diagnostic and therapeutic purposes. Sedation during FFB. along with the introduction of the bronchoscope into the pediatric airway, may cause hypoventilation, leading to hypoxia and desaturation, even in the presence of oxygen supplementation. Arterial oxygen saturation is usually monitored by pulse oximetry (S<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-3.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950160303:tex2gif-inf-3\" \/>) during FFB. End\u2010tidal P<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-5.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950160303:tex2gif-inf-5\" \/> (P<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-7.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950160303:tex2gif-inf-7\" \/>) monitoring is not routinely used. Twenty\u2010two pediatric patients (15 days to 18 years old) undergoing FFB and receiving supplemental oxygen were studied prospectively and had continuous P<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-9.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950160303:tex2gif-inf-9\" \/> and S<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-11.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950160303:tex2gif-inf-11\" \/> measured before and during the procedure (bronchoscope at the carina or either main bronchus). Mean P<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-13.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950160303:tex2gif-inf-13\" \/> (\u00b1SD) decreased from 33.9 (\u00b16.0) mmHg before to 27.1 (\u00b112.1) mmHg during the procedure (P &lt; 0.024). Concomitantly, mean S<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-15.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950160303:tex2gif-inf-15\" \/> (\u00b1SD) also decreased from 99.9 (\u00b10.4)% before to 95.7 (\u00b111.1)% during the procedure (P &lt; 0.015). P<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-17.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950160303:tex2gif-inf-17\" \/> changes seemed to precede the variations in S<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-19.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950160303:tex2gif-inf-19\" \/>, especially in young patients who experienced significant desaturation and decompensation during FFB. We conclude that P<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-21.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950160303:tex2gif-inf-21\" \/> and S<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-23.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950160303:tex2gif-inf-23\" \/> decrease during FFB in children, even with supplemental oxygen. We speculate that this reflects airway obstruction by the instrument. Further studies are needed to assess the utility of P<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-25.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950160303:tex2gif-inf-25\" \/> monitoring in pediatric FFB. Pediatr Pulmonol. 1993; 16:153\u2013157. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1950160303","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T18:38:32Z","timestamp":1173206312000},"page":"153-157","source":"Crossref","is-referenced-by-count":13,"title":["Continuous end\u2010tidal CO<sub>2<\/sub> in pediatric bronchoscopy"],"prefix":"10.1002","volume":"16","author":[{"given":"Luis M.","family":"Franchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Carlos 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