{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T01:49:55Z","timestamp":1774662595279,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T00:00:00Z","timestamp":1129852800000},"content-version":"vor","delay-in-days":4280,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1994,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fifteen adult New Zealand white rabbits were used to determine if exogenous surfactant immediately improves oxygenation in experimental meconium aspiration syndrome (MAS). They were ventilated with 100% 0<jats:sub>2<\/jats:sub> before insufflating 3 mL\/kg of 40% filtered meconium. Arterial blood gases, dynamic lung compliance (C<jats:sub>Ldyn<\/jats:sub>) and resistance (R<jats:sub>L<\/jats:sub>) were monitored for 2 hours before and 1 hour after the intratracheal administration of calf lung surfactant extract or air placebo. The arteriallalveolar O<jats:sub>2<\/jats:sub> tension ratio [P<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-5.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950170202:tex2gif-inf-5\"\/>] increased 133% within 1 hour of surfactant therapy but C<jats:sub>Ldyn<\/jats:sub> did not change. The increase of R<jats:sub>L<\/jats:sub>, was comparable in the surfactant and control groups after meconium instillation. A further increase of 44% in R<jats:sub>L<\/jats:sub> occurred after surfactant administration with no change in the controls. Qualitative histologic analysis confirmed the presence of alveolar meconium as well as inflammation and atelectasis. Persistently elevated R<jats:sub>L<\/jats:sub> suggested airway obstruction in both groups throughout the study. Most likely no increase in C<jats:sub>Ldyn<\/jats:sub> occurred with surfactant administration or it could not be detected because it was measured only with ventilator\u2010induced breaths and ventilator settings were held constant. In the face of airway obstruction C<jats:sub>Ldyn<\/jats:sub> is an inadequate reflection of pulmonary elasticity. We conclude that exogenous surfactant therapy improves oxygenation in this model of MAS. Further studies are needed to understand the mechanism of this improvement. <jats:bold>Pediatr Pulmonol. 1994; 17:75\u201380<\/jats:bold>. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1950170202","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:27:49Z","timestamp":1173209269000},"page":"75-80","source":"Crossref","is-referenced-by-count":28,"title":["Improved oxygenation with exogenous surfactant administration in experimental meconium aspiration syndrome"],"prefix":"10.1002","volume":"17","author":[{"given":"K. 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