{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:00:40Z","timestamp":1779364840152,"version":"3.53.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T00:00:00Z","timestamp":1129852800000},"content-version":"vor","delay-in-days":4252,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1994,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent reports have suggested that substituting continuous negative extrathoracic pressure (CNEP) for positive end\u2010expiratory pressure (PEEP) may result in clinical benefits to infants with pulmonary disease. Other studies have suggested potential hemodynamic advantages. We compared the effects of CNEP and PEEP in 13 mechanically ventilated newborn piglets after acute lung injury induced by saline lavage. The piglets were instrumented, salinelavaged, and exposed to 15 minute periods of incremental CNEP (\u20133, \u20136, \u20139, \u201312 cmH<jats:sub>2<\/jats:sub>O) (n = 7) or PEEP (3, 6, 9, 12 cmH<jats:sub>2<\/jats:sub>O) (n = 6). We measured and\/or calculated dynamic lung compliance (C<jats:sub>Ldyn<\/jats:sub>), lung resistance (R<jats:sub>L<\/jats:sub>), end\u2010expiratory lung volume (EELV), blood gases, cardiac output (CO), heart rate (HR), transmural vascular pressures, and pulmonary and systemic vascular resistance. Pulmonary function abnormalities after saline lavage included decreased P<jats:sub>a<\/jats:sub><jats:sub>o<\/jats:sub><jats:sub>2<\/jats:sub>, C<jats:sub>Ldyn<\/jats:sub>, EELV, and increased P<jats:sub>a<\/jats:sub>co<jats:sub>2<\/jats:sub> and R<jats:sub>L<\/jats:sub> (P &lt; 0.05). Except for decreased CO, lung inflation with both CNEP and PEEP resulted in large increases in P<jats:sub>a<\/jats:sub>O<jats:sub>2<\/jats:sub> without major pulmonary or hemodynamic effects. Other than differences in EELV at 3, 6, and 9 cmH<jats:sub>2<\/jats:sub>O distending pressure, there were no differences in pulmonary function or hemodynamics between sequences of incremental CNEP and PEEP. We conclude that CNEP and PEEP are physiologically equivalent in this model of acute lung injury. <jats:bold>Pediatr Pulmonol. 1994; 17:161\u2013168.<\/jats:bold> \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1950170305","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:24:38Z","timestamp":1173209078000},"page":"161-168","source":"Crossref","is-referenced-by-count":22,"title":["Continuous negative extrathoracic pressure versus positive end\u2010expiratory pressure in piglets after saline lung lavage"],"prefix":"10.1002","volume":"17","author":[{"given":"David","family":"Easa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Mundie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuuleialoha 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