{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T05:51:02Z","timestamp":1698213062137},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T00:00:00Z","timestamp":1129852800000},"content-version":"vor","delay-in-days":4221,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1994,4]]},"abstract":"Abstract<\/jats:title>Persistent pulmonary hypertension of the newborn (PPHN) is associated with multiple cardiopulmonary diseases. Therapy often includes hyperventilation\/alkalosis despite little evidence as to its efficacy in diverse conditions. To determine (1) if part of the improvement of arterial oxygen tension (P) attributed to alkalosis is actually related to increased mean airway pressure (Paw<\/jats:sub>) and (2) if the presence of radiographic pulmonary disease predicts the response to alkalosis or mean airway pressure, we reviewed records of 19 newborns with well\u2010documented PPHN. Arterial blood gases and corresponding ventilator settings were recorded during the first day of life. To adjust for lower F corrected P(cP) was calculated when the F < 1.0, such that cP = calculated arterial\/alveolar oxygen ratio x (71 3 \u2010 P\/0.8). Regression equations were obtained and mean slopes of these were compared for Paw<\/jats:sub> vs. cP, and pH vs. cP by one group t\u2010tests (with assumed population slope of zero). There was no correlation between Paw<\/jats:sub> and cP (mean slope \u00b1 SD = \u22128.4 \u00b1 30.8, P = 0.25), but there was a moderate correlation between p d and cP (mean slope = 333.1 \u00b1 480.5, P = 0.007). Patients were then classified by chest radiographs as having severe or minima\/no lung disease. Relationships of Paw<\/jats:sub> and pH to cP were then re\u2010examined. No correlation was present between Paw<\/jats:sub> and cP, in 11 patients with PPHN and severe radiographic disease (mean slope = \u22127.4 \u00b1 26.97 P = 0.38) or in eight patients with PPHN and minima\/no lung disease (mean slope = \u22129.8 2 37.5, P = 0.48). There was no correlation between pH and CP in patients with severe radiographic lung disease and PPHN (mean slope = 92.1 t 399.5, P 7 0.46), but patients with PPHN and minimal\/no lung disease showed a strong correlation (mean slope = 664.5 \u00b1 385.8, P = 0.002). We conclude that Paw (\u226418 cm H2<\/jats:sub>,O) with conventional mechanical ventilation has no apparent effect on oxygenation in patients with PPHN regardless of lung disease; however, severe radiographic lung disease may be a predominant variable predicting a poor response to alkalosis. We speculate that different diseases cause pulmonary hypertension by different mechanisms. Pediatr Pulmonol. 1994; 17:239\u2013245.<\/jats:bold> \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1950170407","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:22:52Z","timestamp":1173208972000},"page":"239-245","source":"Crossref","is-referenced-by-count":1,"title":["Radiographic lung disease and response of persistent pulmonary hypertension to mean airway pressure and alkalosis"],"prefix":"10.1002","volume":"17","author":[{"given":"Karl S.","family":"Deluga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan E.","family":"Schlesinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,21]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"87","article-title":"\u201cPFC\u201d syndrome (Persistence of the fetel circulation)","volume":"39","author":"Gersony WM","year":"1969","journal-title":"Circulation"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(76)80404-0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1542\/peds.59.2.205","article-title":"Pulm9nary hyertension and the perinatat aspiration syndromes","volume":"59","author":"Fox WW","year":"1977","journal-title":"Pediatrics"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02083142"},{"key":"e_1_2_1_6_2","first-page":"725","article-title":"Beta\u2010hemolytic Streptococcal infecitoon appearing as persistent fetal circulation","volume":"136","author":"Shankaran S","year":"1982","journal-title":"Am J Dis Child."},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1542\/peds.76.4.488","article-title":"Management of infants with severe respiratiory failure and persistence of the fctal circulatiomn, without hyperventilation","volume":"76","author":"Wung JT","year":"1985","journal-title":"Pcdiatrics"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)81239-6"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80775-5"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198509000-00004"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.48.8.612"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80372-8"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198903000-00006"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.62.2.821"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199202000-00006"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1988.02150030093030"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198303000-00004"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198512000-00009"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1542\/peds.40.4.709","article-title":"Neonatal pulmonary ischemia part I: Clinical and physiologic studies","volume":"40","author":"Chu J","year":"1967","journal-title":"Pediatrics"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000240146"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30900-X"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.1950170407","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.1950170407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T03:09:05Z","timestamp":1698116945000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.1950170407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,4]]}},"alternative-id":["10.1002\/ppul.1950170407"],"URL":"https:\/\/doi.org\/10.1002\/ppul.1950170407","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4]]}}}