{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:24Z","timestamp":1761058644300},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T00:00:00Z","timestamp":1129852800000},"content-version":"vor","delay-in-days":4099,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1994,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aerosolized furosemide has been shown to prevent the worsening of different variables in pulmonary function testing, following exercise or bronchial provocation with numerous agents. To investigate if aerosolized furosemide has a bronchodilator effect, we performed two prospective, randomized, placebo\u2010controlled, double\u2010blinded and crossover studies of four aerosol regimens in children with mild chronic asthma. In a pilot study examining three different doses of furosemide in 11 children, the dose of 1.0 mg\/kg resulted in a mean maximum increase of 30.0 \u00b1 6.8% in forced expiratory flow between 25 and 75% vital capacity (FEF<jats:sub>25\u201375<\/jats:sub>), compared with a 3.1 \u00b1 6.8% increase after aerosolized normal saline. The effect was observed after 10 minutes with a mean percent change of 17.7 \u00b1 1.7% from baseline, that persisted to 30 minutes (19.3 \u00b1 3.7%) and was significantly greater than that seen following aerosolized placebo (1.4 \u00b1 2.9% and 0.7 \u00b1 3.4%. respectively; P &lt; 0.05). We then compared the effect of furosemide with that of aerosolized albuterol (0.15 mg\/kg) in 18 patients. There was no statistically significant difference in the improvement observed in forced expiratory volume in 1 second (FEV<jats:sub>1<\/jats:sub>) for albuterol (15.0 \u00b1 2.7%) compared with furosemide (12.1 \u00b1 2.9%) or in FEF<jats:sub>25\u201375<\/jats:sub> (42.9 \u00b1 9.0% versus 26.3 \u00b1 6.7%). The addition of albuterol to furosemide resulted in a 17.2 f 5.9% increase in FEV, and a 51.1 2 13.9% increase in FEF<jats:sub>25\u201375<\/jats:sub>. Our results indicate that aerosolized furosemide has a bronchodilator effect in children with mild stable asthma.<jats:bold>Pediatr Pulmonal. 1994;18:93\u201398.<\/jats:bold> \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1950180207","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:39:39Z","timestamp":1173209979000},"page":"93-98","source":"Crossref","is-referenced-by-count":16,"title":["Reversal of bronchial obstruction in children with mild stable asthma by aerosolized furosemide"],"prefix":"10.1002","volume":"18","author":[{"given":"Terry","family":"Chin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Franchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliezer","family":"Nussbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,21]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"S71","article-title":"Leakage of macromolecules from the tracheobronchial microcirculation","volume":"135","author":"Persson CGA","year":"1987","journal-title":"Am Rev Respir Dis."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)90408-G"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92540-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198910193211602"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(90)90215-P"},{"key":"e_1_2_1_7_2","first-page":"412A","article-title":"Inhaled furosemide is highly effective in preventing ultrasonically nebulized water bronchoconstriction","volume":"137","author":"Robuschi M","year":"1988","journal-title":"Am Rev Respir Dis."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.3.561"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(90)90072-C"},{"key":"e_1_2_1_10_2","first-page":"851P","article-title":"Effect of inhaled furosemide on metabisulphite and methacholine\u2010induced bronchoconstriction and nasal potentials in asthmatic subjects","volume":"44","author":"Nichol GM","year":"1989","journal-title":"Thorax."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.6.1329"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.1.225"},{"key":"e_1_2_1_13_2","volume-title":"Pulmonary Function Testing in Children. 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