{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:50:23Z","timestamp":1763967023981},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,10,24]],"date-time":"2005-10-24T00:00:00Z","timestamp":1130112000000},"content-version":"vor","delay-in-days":4071,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1994,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pulmonary involvement has been documented in thalassemia major (TM). We studied 12 patients with TM before and 24 hr after transfusion to evaluate the effect of transfusion on baseline lung function. Personal and family histories of respiratory illnesses were obtained by a questionnaire. Spirometry and carbon monoxide diffusion capacity (KCO) measurements were made. Blood gases (P<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-1.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950180304:tex2gif-inf-1\" \/>, and S<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-3.gif\" xlink:title=\"urn:x-wiley:87556863:media:PPUL1950180304:tex2gif-inf-3\" \/>,) were determined on arterialized samples. Baseline expiratory volumes and flows were within normal range in all patients. Transfusion resulted in a significant reduction of forced expiratory volume in 1 sec (FEV<jats:sub>1<\/jats:sub>) and forced expiratory flow between 25 and 75% vital capacity (FEF<jats:sub>25\u201375%<\/jats:sub>). In two subgroups of patients identified by the questionnaire, those with no history of airway disease had normal baseline flows and no posttransfusion changes; those with history of airway obstruction had lower pretransfusion flows and significantly decreased posttransfusion FEV<jats:sub>1<\/jats:sub> and FEF<jats:sub>25\u201375%<\/jats:sub>. The mean pretransfusion KCO value of 80% predicted for the whole group, significantly increased after transfusion (P &lt; 0.05). Blood gases also significantly increased after transfusion (P &lt; 0.05). When tested for the spirometric response to albuterol, patients with a history of asthma had a slightly greater increase in FEV<jats:sub>1<\/jats:sub> and FEF<jats:sub>25\u201375%<\/jats:sub> than those who had never had asthma. We conclude that in our small study group, transfusion resulted in improved gas exchange and lung perfusion. The effect on flow limitation evident in some patients could, in part, be related to a preexisting bronchial hyperreactivity. Accurate evaluation of pulmonary function and of bronchial reactivity is advisable for patients with TM. <jats:bold>Pediatr Pulmonol. 1994;18:139\u2013143.<\/jats:bold> \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1950180304","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:39:36Z","timestamp":1173209976000},"page":"139-143","source":"Crossref","is-referenced-by-count":22,"title":["The effect of transfusion on pulmonary function in patients with thalassemia major"],"prefix":"10.1002","volume":"18","author":[{"given":"F.","family":"Santamaria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P.","family":"Villa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Werner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cutrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ronchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,24]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Hematology of Infancy and Childhood","author":"McDonagh KT","year":"1993"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1542\/peds.65.5.1013","article-title":"Pulmonary function abnormalities in thalassemia patients on a hypertransfusion program","volume":"65","author":"Keens TG","year":"1980","journal-title":"Pediatrics"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80116-0"},{"key":"e_1_2_1_5_2","first-page":"639","article-title":"Low lung capacity and hypoxemia in children with thalassemia major","volume":"121","author":"Cooper DM","year":"1980","journal-title":"Am Rev Respir Dis."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80113-0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.98.5.1138"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198601000-00005"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950110411"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.2.362"},{"issue":"6","key":"e_1_2_1_11_2","first-page":"36","article-title":"Epidemiology standardization project","volume":"118","author":"Ferris BJ","year":"1978","journal-title":"Am Rev Respir Dis."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(74)90347-9"},{"key":"e_1_2_1_13_2","volume-title":"Lung Function Assessment and Application in Medicine","author":"Cotes JE","year":"1979"},{"key":"e_1_2_1_14_2","first-page":"95","article-title":"Diagnostic problems in asthma","volume":"55","author":"Konig P","year":"1985","journal-title":"Ann Allergy"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197404042901402"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.27.8.652"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.1950180304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.1950180304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T14:40:08Z","timestamp":1698158408000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.1950180304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,9]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,9]]}},"alternative-id":["10.1002\/ppul.1950180304"],"URL":"https:\/\/doi.org\/10.1002\/ppul.1950180304","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,9]]}}}