{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:35:45Z","timestamp":1760297745574},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,10,24]],"date-time":"2005-10-24T00:00:00Z","timestamp":1130112000000},"content-version":"vor","delay-in-days":4071,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1994,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>By improving pulmonary function in patients with cystic fibrosis (CF), recombinant human deoxyribonuclease (rhDNase) may affect resting energy expenditure (REE). To examine this hypothesis, we measured REE by indirect calorimetry in seven patients with CF before (day 0) and 2 weeks after (day 15) administration of aerosolized rhDNase. Baseline REE was higher in all patients than predicted for age, sex, and weight (mean \u00b1 SEM 128\u00b14.9%; range, 116\u2013147%). After 2 weeks of aerosolized rhDNase, mean forced vital capacity (FVC) (in % of predicted values) improved significantly from 54.1 \u00b1 2.2 to 66.3\u00b14.2% (mean improvement, 12.3%; 95% Cl, 2.8,21; <jats:italic>P<\/jats:italic> &lt; 0.05) and REE decreased by 11.0% (95% Cl 3.2, 17.5; <jats:italic>P<\/jats:italic> &lt; 0.05). In addition, the larger the improvement in FVC in response to rhDNase the greater the decrease in energy expenditure (<jats:italic>r<\/jats:italic> \u2013 0.88). The REE decreased in all patients who had an increase in FVC and remained unchanged in two patients who had no change in FVC. We conclude that patients with CF whose lung function improve in response to aerosolized rhDNase have an acute and proportionate reduction in their resting energy expenditure.<jats:bold>Pediatr Pulmonol. 1994;18:150\u2013154.<\/jats:bold> \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1950180306","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:39:36Z","timestamp":1173209976000},"page":"150-154","source":"Crossref","is-referenced-by-count":16,"title":["Effects of administration of aerosolized recombinant human deoxyribonuclease on resting energy expenditure in patients with cystic fibrosis"],"prefix":"10.1002","volume":"18","author":[{"given":"Nikhil","family":"Amin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen J.","family":"Dozor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198302010-00005"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80107-5"},{"key":"e_1_2_1_4_2","first-page":"130","article-title":"Increased energy expenditure in young children with cystic fibrosis","volume":"1","author":"Shepherd RW","year":"1988","journal-title":"Lancet"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199102000-00014"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83042-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1152\/jappl.1988.64.5.1810","article-title":"Increased energy expenditure in cystic fibrosis","volume":"64","author":"Buchdahl RM","year":"1988","journal-title":"J Appl Physiol."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198209233071304"},{"key":"e_1_2_1_9_2","first-page":"199","article-title":"Studies on pulmonary secretions I. The overall chemical composition of pulmonary secretions from patients with cystic fibrosis, bronchiectesis and laryngectomy","volume":"88","author":"Mathews LS","year":"1963","journal-title":"Am Rev Resp Dis."},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1183\/09031936.93.03010019","article-title":"The origin of DNA associated with mucus glycoproteins in cystic fibrosis sputum","volume":"3","author":"Leham ML","year":"1990","journal-title":"Eur Respir Jr."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.23.9188"},{"key":"e_1_2_1_12_2","first-page":"759","article-title":"Liquification of viscous purulent exudate by deoxyribonuclease","volume":"2","author":"Armstrong JB","year":"1950","journal-title":"Lancet"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199203193261207"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1001\/jama.1992.03480140073036","article-title":"Effects of inhaled recombinant human DNase on pulmonary function in normal and cystic fibrosis patients. Phase 1 Study","volume":"262","author":"Aitken ML","year":"1992","journal-title":"JAMA"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.1.145"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1093\/ajcn\/34.11.2530","article-title":"Norms for nutritional assessment of American adults by upper arm anthropometry","volume":"34","author":"Bishop CW","year":"1981","journal-title":"AM J Clin Nutr."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(85)80167-6"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/34.11.2540"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80039-4"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.5.1285"},{"key":"e_1_2_1_21_2","first-page":"100","volume-title":"Pulmonary Testing in Children","author":"Polgar P","year":"1971"},{"key":"e_1_2_1_22_2","first-page":"725","article-title":"Changes in the normal maximal expiratory flow\u2010volume curves with aging","volume":"127","author":"Knudson RJ","year":"1983","journal-title":"Am Rev Resp Dis."},{"key":"e_1_2_1_23_2","first-page":"581","article-title":"The maximal expiratory flow\u2010volume curve","volume":"113","author":"Knudson RJ","year":"1976","journal-title":"Am Rev Resp Dis."},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1949.sp004363"},{"key":"e_1_2_1_25_2","series-title":"World Health Organization Technical Report Series #724","volume-title":"Energy and protein requirements\u2010Report of FAO\/WHO\/UNU expert consultation","author":"World Health Organization","year":"1985"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1093\/ajcn\/45.6.1420","article-title":"Comparison of indirect calorimetric measurements of resting energy expenditure with a ventilated hood, face mask and mouth piece","volume":"45","author":"Segal KE","year":"1987","journal-title":"Am J Clin Nutr."},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/0148607191015002165"},{"key":"e_1_2_1_28_2","unstructured":"ChernickWS BarberoGJ EichelHJ.In vitro evaluation of effect of enzymes on tracheobronchial secretions from patients with cystic fibrosis. Pediatrics1961;27589\u2013596."},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1001\/jama.1968.03140310070022","article-title":"Dornase aerosol effects on sputum viscosity in cases of cystic fibrosis","volume":"205","author":"Lieberman J","year":"1968","journal-title":"JAMA"},{"key":"e_1_2_1_30_2","unstructured":"FuchsHJ BorowitzD ChristiansonD et al. Aerosolized recombinant human DNase reduces pulmonary exacerbations and improves pulmonary function in patients with CF\u2014presented by Wohl ME at the 36th Annual Conference on Chest Diseases Intermountain Thoracic Society 1993."}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.1950180306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.1950180306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T14:40:27Z","timestamp":1698158427000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.1950180306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,9]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,9]]}},"alternative-id":["10.1002\/ppul.1950180306"],"URL":"https:\/\/doi.org\/10.1002\/ppul.1950180306","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,9]]}}}