{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T19:38:46Z","timestamp":1768073926115,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T00:00:00Z","timestamp":1129852800000},"content-version":"vor","delay-in-days":4038,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report our experience giving aerosolized pentamidine as prophylaxis for <jats:italic>Pneumocystis carinii<\/jats:italic> pneumonia (PCP) to 9 children (mean age, 7.33 years; range 3\u201317 years) with leukemia who were unable to tolerate trimethoprim\u2010sulfamethoxazole (TMP\u2010SMX) due to allergy or myelosuppression. The dose of pentamidine was modified for each child to correct for weight and approximate alveolar ventilation. We were able to administer the drug to younger children by using a cushioned face mask in place of the standard mouthpiece. One child experienced moderate coughing with administration of pentamidine. He and four others with a past medical history suggestive of reactive airways disease were pretreated with inhaled albuterol. No other adverse effects were noted. Treatment lasted an average of 8.11 \u00b1 4.1 months per child; no case of PCP occurred. We conclude that aerosolized pentamidine can be administered to even very young children and may be of benefit to all immunosuppressed children unable to use TMP\u2010SMX prophylaxis. The adjusted dose used here appears to be safe, but further studies regarding drug delivery and efficacy are needed.<jats:bold>Pediatr Pulmonol. 1994;18:226\u2013231<\/jats:bold>. \u00a91994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1950180406","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:38:12Z","timestamp":1173209892000},"page":"228-231","source":"Crossref","is-referenced-by-count":11,"title":["The use of aerosolized pentamidine for prophylaxis of <i>Pneumocystis carinii<\/i> pneumonia in children with leukemia"],"prefix":"10.1002","volume":"18","author":[{"given":"Brian P.","family":"O'Sullivan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhoda","family":"Spaulding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930115)71:2<481::AID-CNCR2820710232>3.0.CO;2-S"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480060078034"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706253162604"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199104183241602"},{"issue":"2","key":"e_1_2_1_6_2","first-page":"1","article-title":"Guidelines for prophylaxis against Pneumocystis carinii pneumonia for children infected with human immunodeficiency virus","volume":"40","author":"Centers for Disease Control","year":"1991","journal-title":"MMWR"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-11-948"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62478-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212243272606"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199204000-00006"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02072640"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199112000-00022"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1200\/JCO.1994.12.1.136","article-title":"Successful Pneumocystis carinii pneumonia prophylaxis using aerosolired pentamidine in children with acute leukemia","volume":"12","author":"Weinthal J","year":"1994","journal-title":"J Clin Oncol."},{"key":"e_1_2_1_14_2","first-page":"54","volume-title":"Pediatric Anesthesia","author":"Crone RK","year":"1983"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.1950180406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.1950180406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:43:24Z","timestamp":1698126204000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.1950180406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,10]]}},"alternative-id":["10.1002\/ppul.1950180406"],"URL":"https:\/\/doi.org\/10.1002\/ppul.1950180406","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10]]}}}