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The response to cold air was expressed as the percent drop in FEV<jats:sub>1<\/jats:sub> from baseline at 4 min. after the challenge (\u0394% FEV<jats:sub>1<\/jats:sub> CAH), and the response to methacholine as the provocative concentration required to reduce the FEV<jats:sub>1<\/jats:sub> by 20% from baseline (PC<jats:sub>20<\/jats:sub>MCH). Both tests were sensitive (94%) for detecting airway hyperreactivity. There was no statistically significant relationship between A% FEV, CAH and the log PC<jats:sub>20<\/jats:sub>MCH (<jats:italic>r<\/jats:italic> = 0.39; <jats:italic>P<\/jats:italic> = 0.12). In clinical practice, methacholine test is easier to perform, but in the research field cold air challenge may be preferable because it avoids potential drug effects. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1950190603","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T20:55:44Z","timestamp":1173214544000},"page":"326-329","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of airway reactivity induced by cold air and methacholine challenges in asthmatic children"],"prefix":"10.1002","volume":"19","author":[{"given":"Fernando M.","family":"de Benedictis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard J.","family":"Canny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian B.","family":"MacLusky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Levison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,21]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Expert Panel Report. 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