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We report three siblings with apnea and periodic breathing, as well as biochemical defects consistent with a non\u2010specific abnormality of beta oxidation. One infant died a witnessed sudden infant death. The two survivors were treated with L\u2010carnitine supplementation resulting in rapid resolution of both respiratory and metabolic abnormalities. Enzyme activity for short, medium, and long chain acyl coenzyme A dehydrogenases was normal in these two infants. Although a unique enzymatic deficiency was not identified, our experience with this family supports the need for routine biochemical evaluation of infants with \u201cnear miss\u201d SIDS, also called acute life\u2010threatening events (ALTE), as well as those who have died of SIDS. <jats:bold>Pediatr Pulmonol. 1995; 20:167\u2013171<\/jats:bold>. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1950200307","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T21:11:51Z","timestamp":1173215511000},"page":"167-171","source":"Crossref","is-referenced-by-count":15,"title":["Familial infantile apnea and immature beta oxidation"],"prefix":"10.1002","volume":"20","author":[{"given":"A. 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