{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:16:53Z","timestamp":1774567013181,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T00:00:00Z","timestamp":1129852800000},"content-version":"vor","delay-in-days":3673,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effectiveness of maintenance albuterol aerosol therapy in cystic fibrosis (CF) was assessed by comparing spirometric measurements at the beginning and end of 1 year. Peak expiratory flow rates (PEFR) were measured twice daily to determine bronchodilator responsiveness and spontaneous diurnal variation (SDV), and results were compared with groups of normal and asthmatic children. CF patients not receiving regular albuterol therapy served as a control group. In the treatment group, forced vital capacity (FVC) and forced expiratory volume in the first second (FEV<jats:sub>1<\/jats:sub>) were significantly increased (12.2% and 18.4%, respectively) over the course of the treatment year, as contrasted with a significant decrease during the preceding year. During the study year the CF control group had a significant decrease in FEV<jats:sub>1<\/jats:sub> and FEF<jats:sub>25\u201375%<\/jats:sub> and the difference between treatment and control groups was significant for FVC, FEV<jats:sub>1<\/jats:sub>, and FEF<jats:sub>25\u201375%<\/jats:sub> PEFR increased from the first to the last week of the year\u2010long observation period (from 71.8% to 78.7% of predicted values, <jats:italic>P<\/jats:italic> &lt; 0.01). Spontaneous diurnal variations were significantly greater in the CF study group than a group of normal children; SDV decreased significantly in the treatment group during the year of study. A bronchodilator response of &gt; 15% was present in 25.8% of CF patient days, but there was considerable interpatient variability. Frequent bronchodilator responders were accurately predicted by their baseline bronchodilator responsiveness, but not by age or personal or family history of asthma or atopy. No difference in long\u2010term pulmonary function improvements were noted between frequent and infrequent responders. The results suggest that maintenance albuterol aerosol treatments reversed the progressive downward course in lung function in the CF treatment group. A double\u2010blind placebo\u2010controlled study is required to confirm these preliminary findings. <jats:bold>Pediatr Pulmonol. 1995; 20:205\u2013214<\/jats:bold>. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1950200402","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T21:11:40Z","timestamp":1173215500000},"page":"205-214","source":"Crossref","is-referenced-by-count":26,"title":["Short\u2010term and long\u2010term effects of albuterol aerosol therapy in cystic fibrosis: A preliminary report"],"prefix":"10.1002","volume":"20","author":[{"given":"Peter","family":"K\u00f6nig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra","family":"Gayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio J.","family":"Barbero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette","family":"Shaffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.56.6.455"},{"key":"e_1_2_1_3_2","first-page":"889","article-title":"A longitudinal study of bronchodilator responsiveness in cystic fibrosis","volume":"131","author":"Hordvik NL","year":"1985","journal-title":"Am Rev Respir Dis."},{"key":"e_1_2_1_4_2","first-page":"131","article-title":"Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection","volume":"113","author":"Empey DW","year":"1976","journal-title":"Am Rev Respir Dis."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.35.7.531"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000194281"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.35.10.768"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80085-X"},{"key":"e_1_2_1_9_2","first-page":"399","article-title":"A comparative study of inhaled atropine sulfate and isoproterenol hydrochloride in cystic fibrosis","volume":"119","author":"Larsen GL","year":"1979","journal-title":"Am Rev Respir Dis."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.99.5.1088"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)93098-A"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6815.1426"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.37.6.423"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.41.10.771"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/014107688007301009"},{"key":"e_1_2_1_16_2","first-page":"859","article-title":"Within\u2010subject variability and per cent change for significance of spirometry in normal subjects and in patients with cystic fibrosis","volume":"122","author":"Nickerson BG","year":"1980","journal-title":"Am Rev Respir Dis."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/32.3.607"},{"key":"e_1_2_1_18_2","first-page":"725","article-title":"Changes in the normal maximal expiratory flow\u2010volume curve with growth and aging","volume":"127","author":"Knudson RJ","year":"1983","journal-title":"Am Rev Respir Dis."},{"key":"e_1_2_1_19_2","first-page":"192","article-title":"Ventilatory function of normal children and young adults, Mexican\u2010American, white and black: IIWright peak flow meter","volume":"95","author":"Hsu KHK","year":"1979","journal-title":"J Pediatr."},{"key":"e_1_2_1_20_2","volume-title":"Lung Function. 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