{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T02:19:12Z","timestamp":1744165152410},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T00:00:00Z","timestamp":1129852800000},"content-version":"vor","delay-in-days":3612,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[1995,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A multiple\u2010breath nitrogen washout system designed to measure lung volume in mechanically ventilated infants was validated by assessing three performance criteria: (1) accuracy of lung volume measurements in the presence of an endotracheal tube leak was assessed by comparing the measurements of functional residual capacity (FRC) in a mechanical lung model with and without airway leak; (2) in vivo accuracy was assessed in rabbits by comparing FRC measurements obtained by this system with measurements obtained by helium dilution; and (3) in vivo precision was assessed by analyzing measurements of FRC obtained in replicate measurements at different times in ventilator\u2010dependent premature infants with hyaline membrane disease. The average difference between the measurements of FRC in a mechanical lung model with airway leak and without leak was 3.0 \u00b1 9.4% (mean \u00b1 SD, P &gt; 0.2), and no difference was greater than 20%. There was a significant correlation between the measurements of FRC in rabbits by nitrogen washout and by helium dilution (r = 0.93, P &lt; 0.000l), and 65.4% of the paired measurements were within 20% of their average. The 95% limits of agreement within pairs of measurements by the two techniques ranged from \u22124.0 to +6.5 mLkg. FRC measured by helium dilution was slightly higher (1.3 \u00b1 2.7mUkg, P &lt; 0.01) than FRC measured by nitrogen washout, and positive end\u2010expiratory pressure was a significant predictor of this difference (P &lt; 0.01). The regression between the individual FRC measurements obtained in premature infants and the average of the other replicates was significant (6 &gt; 0.98, P &lt; 0.0001). The coefficient of variation was 12.3%. These findings provide further validation of this multiple\u2010breath nitrogen washout system for measuring FRC in premature infants during mechanical ventilation. <jats:bold>Pediatr Pulmonol. 1995; 20:403\u2013409<\/jats:bold>. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.1950200611","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T21:11:07Z","timestamp":1173215467000},"page":"403-409","source":"Crossref","is-referenced-by-count":9,"title":["Validation of a nitrogen washout system to measure functional residual capacity in premature infants with hyaline membrane disease"],"prefix":"10.1002","volume":"20","author":[{"given":"Jason","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy B.","family":"Law","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5kan W.","family":"Sundell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Lindstrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert B.","family":"Cotton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198604000-00007"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000243843"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82057-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198411000-00021"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199011000-00005"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02441610"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198711000-00020"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1990.tb11550.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199111000-00019"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199310000-00022"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199111000-00020"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(70)80328-6"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1152\/jappl.1977.43.4.755","article-title":"Instrumentation for measuring functional residual capacity in small animals","volume":"43","author":"Koen PA","year":"1977","journal-title":"J Appl Physiol."},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1152\/jappl.1988.64.4.1607","article-title":"Lung volume recruitment during high\u2010frequency oscillation in atelectasis\u2010prone rabbits","volume":"64","author":"Byford LJ","year":"1988","journal-title":"J Appl Physiol."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950130414"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950160310"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","unstructured":"GerhardtT HehreD BancalariE WatsonH. A simple method for measuring functional residual capacity by N2washout in small animals and newborn infants. 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