{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:21:47Z","timestamp":1771262507633,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T00:00:00Z","timestamp":1085356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We previously reported on a 7\u2010day course of dexamethasone starting at 0.5 mg\/kg\/day in intubated very low birth weight (VLBW) infants, 7\u201314 days of age, with increased dynamic pulmonary compliance and decreased bronchopulmonary dysplasia (BPD). The effect of low\u2010dose dexamethasone on functional residual capacity (FRC) in VLBW infants is unknown. The objective of this study was to compare the effect of two regimens of moderately early dexamethasone on FRC and passive respiratory compliance (Crs) in VLBW infants at risk for BPD. Sixty\u2010two intubated VLBW infants were randomized (double\u2010blinded) at 7\u201321 days of age; 29 patients (mean birth weight, 839 g) received \u201chigh\u201d dose dexamethasone (0.5 mg\/kg\/day for 3 days, 0.25 mg\/kg\/day for 3 days, and 0.1 mg\/kg\/day on day 7, total dose of 2.35 mg\/kg), and 33 infants (mean birth weight, 830 g) received \u201clow\u2010dose\u201d dexamethasone (0.2 mg\/kg\/day for 3 days and 0.1 mg\/kg\/day for 4 days, total dose of 1 mg\/kg). FRC and Crs were measured with the nitrogen washout technique and single breath occlusion technique, before and on days 2, 5, and 7 of therapy. Clinical outcome and early neurodevelopmental follow\u2010up were evaluated. FRC significantly increased in the high\u2010dose (19.3 ml\/kg at baseline to 34 ml\/kg on day 7; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and low\u2010dose (18.1 ml\/kg at baseline to 30.3 ml\/kg on day 7; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) dexamethasone groups when compared to baseline. There was a significant increase in Crs and a decrease in FiO<jats:sub>2<\/jats:sub> within each group. The improvements in FRC and Crs were comparable between groups, and specific compliances (Crs\/FRC) were not different. There were no significant differences in other clinical outcome parameters, including BPD and neurodevelopmental outcome. In conclusion, there are significant increases in FRC during a 7\u2010day course of moderately early dexamethasone in VLBW infants. The lower total dose (1 mg\/kg) appears as effective as the higher total dose of dexamethasone (2.35 mg\/kg) in increasing FRC. Comparable significant increases in Crs were observed in both groups of infants. Additional long\u2010term follow\u2010up is underway. Pediatr Pulmonol. 2004; 38:55\u201363. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20037","type":"journal-article","created":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T19:00:59Z","timestamp":1085425259000},"page":"55-63","source":"Crossref","is-referenced-by-count":30,"title":["Randomized, double\u2010blinded trial of low\u2010dose dexamethasone: II. Functional residual capacity and pulmonary outcome in very low birth weight infants at risk for bronchopulmonary dysplasia"],"prefix":"10.1002","volume":"38","author":[{"given":"Cindy","family":"McEvoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Bowling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pam","family":"McGaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Durand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,24]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"The Cochrane library","author":"Halliday HL","year":"2003"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.79.1.F26"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1542\/peds.95.4.584","article-title":"Effects of early dexamethasone therapy on pulmonary mechanics and chronic lung disease in very low birth weight infants: a randomized, controlled trial","volume":"95","author":"Durand M","year":"1995","journal-title":"Pediatrics"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70410-8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.3.741"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199407001-00022"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198906083202301"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1070"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.108876"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199310000-00022"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199912000-00007"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.62.1.825"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.2.262"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198511000-00010"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950160310"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.2.280"},{"key":"e_1_2_1_18_2","first-page":"552","article-title":"Passive respiratory mechanics in newborns and children","volume":"129","author":"LeSouef PN","year":"1984","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950150408"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.2.474"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70360-3"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950130303"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200106283442602"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050823"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199804000-00017"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.1.71"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198704000-00001"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950080209"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(09)90024-5"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81155-2"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90210-4"},{"key":"e_1_2_1_32_2","first-page":"109","article-title":"Controlled trial of early dexamethasone treatment for the prevention of chronic lung disease in preterm infants: a 3\u2010year follow\u2010up","author":"Romagnoli C","year":"2002","journal-title":"Pediatrics"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101113440203"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.1.15"},{"key":"e_1_2_1_35_2","first-page":"101","article-title":"Early dexamethasone therapy in preterm infants: a follow\u2010up study","author":"Yeh TF","year":"1998","journal-title":"Pediatrics"},{"key":"e_1_2_1_36_2","first-page":"438","article-title":"School\u2010age outcome in children with early postnatal dexamethasone therapy for prevention of CLD of prematurity","volume":"53","author":"Yeh TF","year":"2003","journal-title":"Pediatr Res"},{"key":"e_1_2_1_37_2","first-page":"3","article-title":"Postnatal dexamethasone for bronchopulmonary dysplasia: a systematic review and meta\u2010analysis of 20 years of clinical trials","author":"Banks BA","year":"2002","journal-title":"Neoreviews"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.19.3.269"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.77.2.458"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-5-1-25"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.2.330"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20037","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.20037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T18:55:27Z","timestamp":1700160927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.20037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,24]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1002\/ppul.20037"],"URL":"https:\/\/doi.org\/10.1002\/ppul.20037","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5,24]]}}}