{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:41:22Z","timestamp":1770432082291,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,1,24]],"date-time":"2005-01-24T00:00:00Z","timestamp":1106524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report on an association of idiopathic CD4+ lymphocytopenia (ICL) and juvenile laryngeal papillomatosis (JLP) in a pediatric\u2010aged patient. Because of a past medical history of recurrent lung infections and severe chickenpox in infancy, immunologic investigations were done at age 6 years. On several occasions, a CD4+lymphocyte count of &lt;300 cells\/mm<jats:sup>3<\/jats:sup> was detected, supporting the diagnosis of ICL. During follow\u2010up, both medical (interferon\u2010alpha) and surgical treatments of JLP were only partially efficient. Our patient developed disseminated infection with <jats:italic>Mycobacterium avium<\/jats:italic> and died at 10 years of age. Human papillomavirus is an important pathogen in pediatric and adult patients with ICL. In pediatric patients with JLP who develop other unusually severe viral or opportunistic infections, immunological investigations should be considered. Pediatr Pulmonol. 2005; 39:281\u2013283. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20173","type":"journal-article","created":{"date-parts":[[2005,1,24]],"date-time":"2005-01-24T18:48:48Z","timestamp":1106592528000},"page":"281-283","source":"Crossref","is-referenced-by-count":12,"title":["Idiopathic CD4+ lymphocytopenia and juvenile laryngeal papillomatosis"],"prefix":"10.1002","volume":"39","author":[{"given":"Srdjan","family":"Pasic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Predrag","family":"Minic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slobodan","family":"Dzudovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Minic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bojana","family":"Slavkovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,24]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"541","article-title":"Unexplained CD4+ T\u2010lymphocyte depletion in persons without evident HIV infection","volume":"41","author":"Centers for Disease Control and Prevention","year":"1992","journal-title":"MMWR"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302113280603"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302113280601"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302113280604"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70524-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050236"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.78.4.371"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62917-1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1996.0167"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1001\/archderm.1990.01670360068011","article-title":"Abnormal function of CD4+ helper\/inducer T lymphocytes in a patient with widespread human papillomavirus type 3\u2010related infection","volume":"126","author":"Hansen ER","year":"1990","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02717.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70253-5"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08527.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00364.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2002.290809.x"},{"key":"e_1_2_1_17_2","first-page":"9","article-title":"Structure of immunological defect in laryngeal papillomatosis in children","volume":"4","author":"Tsvetkov EA","year":"1996","journal-title":"Vestn Otorinolaringol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(02)00123-5"},{"key":"e_1_2_1_19_2","first-page":"69","article-title":"Evaluation of immunocompetency in juvenile laryngeal papillomatosis","volume":"65","author":"Perrick D","year":"1990","journal-title":"Ann Allergy"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2002.tb00197.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.119672"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1149"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000424)91:5<368::AID-AJMG10>3.0.CO;2-9"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20173","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.20173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T18:15:58Z","timestamp":1700158558000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.20173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,24]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["10.1002\/ppul.20173"],"URL":"https:\/\/doi.org\/10.1002\/ppul.20173","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1,24]]}}}