{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T05:42:44Z","timestamp":1776490964809,"version":"3.51.2"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,1,24]],"date-time":"2005-01-24T00:00:00Z","timestamp":1106524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Patrick and Catherine Weldon Donoghue Medical Research Foundation"},{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"crossref","award":["U18 HS11147"],"award-info":[{"award-number":["U18 HS11147"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Medicine, University of Manitoba"},{"name":"NIH\/NHLBI","award":["5 T32 HL07427"],"award-info":[{"award-number":["5 T32 HL07427"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["K01 HL04370-01A1"],"award-info":[{"award-number":["K01 HL04370-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Childhood asthma is a major public health problem in the United States, particularly among minority populations. The aim of our study was to examine the relationship among ethnicity, allergen sensitization, spirometric measures, and asthma severity in children with mild to severe asthma who received their medical care in Hartford, Connecticut. Four hundred thirty\u2010eight children aged 4\u201318 years who were enrolled in an asthma care program (Easy Breathing\u00a9) in Hartford and who were referred for spirometry and allergy skin testing participated in this cross\u2010sectional study. Risk factors for increased asthma severity as defined by National Asthma Education and Prevention Program (NAEPP) guidelines were determined using multinomial logistic regression. Of 438 children, 383 (87.4%) had mild to moderate asthma, and 292 (66.7%) had at least one positive skin test to allergens. Forced expiratory volume in 1 sec\/forced vital capacity (FEV<jats:sub>1<\/jats:sub>\/FVC) was significantly decreased in children with severe vs. mild asthma (80.7 vs. 87.3, respectively). In a multivariate analysis, predictors of severe asthma included African\u2010American ethnicity (odds ratio (OR)\u2009=\u20093.70, 95% confidence interval (CI)\u2009=\u20091.10\u201312.42), Puerto Rican ethnicity (OR\u2009=\u20093.55, 95% CI\u2009=\u20091.18\u201310.67), sensitization to cockroach allergen (OR\u2009=\u20094.34, 95% CI\u2009=\u20091.73\u201310.86), and decreased FEV<jats:sub>1<\/jats:sub>\/FVC (OR for every 1% decrease in FEV<jats:sub>1<\/jats:sub>\/FVC\u2009=\u20091.06, 95% CI\u2009=\u20091.02\u20131.11). In conclusion, among children with asthma in Hartford and its surrounding communities, predictors of disease severity included African\u2010American ethnicity, Puerto Rican ethnicity, sensitization to cockroach allergen, and decreased FEV<jats:sub>1<\/jats:sub>\/FVC. Our findings suggest that FEV<jats:sub>1<\/jats:sub>\/FVC is a useful indicator of asthma severity in children. Pediatr Pulmonol. 2005; 39:268\u2013275. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20177","type":"journal-article","created":{"date-parts":[[2005,1,24]],"date-time":"2005-01-24T18:48:40Z","timestamp":1106592520000},"page":"268-275","source":"Crossref","is-referenced-by-count":66,"title":["Predictors of disease severity in children with asthma in Hartford, Connecticut"],"prefix":"10.1002","volume":"39","author":[{"given":"Clare D.","family":"Ramsey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Celed\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane L.","family":"Sredl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott T.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M.","family":"Cloutier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1367\/1539-4409(2002)002<0382:RAIDIC>2.0.CO;2"},{"key":"e_1_2_1_3_2","first-page":"1","article-title":"National survey of prevalence of asthma among children in the United States, 1976 to 1980","volume":"81","author":"Gergen PJ","year":"1988","journal-title":"Pediatrics"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.90.12.1923"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/142.3.555"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.83.4.580"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.9906025"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62973-0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90221-7"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.1.135"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.6.8520740"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705083361904"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1081\/JAS-120017207"},{"key":"e_1_2_1_14_2","first-page":"237","article-title":"Characteristics and diagnoses of cockroach\u2010sensitive bronchial asthma","volume":"68","author":"Kang BC","year":"1992","journal-title":"Ann Allergy"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.7.2103044"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.1.9807104"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.5.1580"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.1.85"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.5.1571"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.116697"},{"key":"e_1_2_1_21_2","first-page":"15","volume-title":"Expert panel report 2: guidelines for the diagnosis and management of asthma","author":"National Asthma Education and Prevention Program","year":"1997"},{"key":"e_1_2_1_22_2","unstructured":"LevyD RodriguezO VillemezW.The changing demographics of Connecticut\u20141999 to 2000. 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