{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:37:06Z","timestamp":1774125426653,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,8,16]],"date-time":"2005-08-16T00:00:00Z","timestamp":1124150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Respiratory syncytial virus (RSV) infection is the most common cause of bronchiolitis in infants and an important risk factor for the development of recurrent wheezing and asthma. Cysteinyl leukotrienes were implicated in the pathophysiology of these diseases, and are being targeted for their diagnosis and therapy. We measured urinary leukotriene E<jats:sub>4<\/jats:sub> (LTE<jats:sub>4<\/jats:sub>) in infants with RSV bronchiolitis in comparison with controls without respiratory infection, and investigated whether medical and family history, age, and passive exposure to tobacco smoke are related to urinary leukotriene excretion. We studied 33 infants with bronchiolitis and 25 controls, 1\u201312 months of age. Demographic and historical data were obtained from informed\u2010consent forms and questionnaires completed by the parents. RSV was detected in nasal secretions by enzyme\u2010linked immunoassay. Urine samples were collected on day of admission and were analyzed for LTE<jats:sub>4<\/jats:sub> with an enzyme\u2010linked immunoassay. Urinary LTE<jats:sub>4<\/jats:sub> was 8\u2010fold higher in infants with bronchiolitis than in controls. Leukotriene excretion was significantly higher in infected infants &lt;6 months of age with a medical history of eczema or dry cough and\/or family history of asthma. Multivariate analysis revealed that eczema and dry cough are independently associated with high LTE<jats:sub>4<\/jats:sub> excretion during bronchiolitis. Exposure to tobacco smoke did not affect urinary LTE<jats:sub>4<\/jats:sub>. Our study shows that leukotriene synthesis during bronchiolitis is particularly elevated in younger infants with an atopic\/asthmatic background. Urinary LTE<jats:sub>4<\/jats:sub> may become a valuable, noninvasive marker for the identification of patients who will benefit most from therapy with leukotriene modifiers for management of bronchiolitis. Pediatr Pulmonol. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20285","type":"journal-article","created":{"date-parts":[[2005,8,16]],"date-time":"2005-08-16T15:17:01Z","timestamp":1124205421000},"page":"285-291","source":"Crossref","is-referenced-by-count":44,"title":["Leukotriene synthesis during respiratory syncytial virus bronchiolitis: Influence of age and atopy"],"prefix":"10.1002","volume":"40","author":[{"given":"Giovanni","family":"Piedimonte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Renzetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Auais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Di Marco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Tripodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Colistro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Villani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Di Ciommo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Cutrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"473","volume-title":"Kendig's disorders of the respiratory tract in children","author":"Wohl ME","year":"1998"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10321-5"},{"key":"e_1_2_1_4_2","first-page":"1501","article-title":"Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7","volume":"161","author":"Sigurs N","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2002.tb00152.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00404602"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1996.02170360056009"},{"key":"e_1_2_1_8_2","first-page":"CD001266","article-title":"Bronchodilators for bronchiolitis","volume":"2","author":"Kellner JD","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)02285-4"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70342-1"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.6.e77"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70316-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.80.4.343"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.82.2.126"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9537"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00323.2001"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198810000-00018"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70235-6"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.5.1533"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(90)90304-G"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1995.tb01079.x"},{"key":"e_1_2_1_22_2","volume-title":"Biostatistical analysis","author":"Zar JH","year":"1984"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.47.1.1"},{"key":"e_1_2_1_24_2","first-page":"244","article-title":"Entry rate and metabolism of leukotriene C4 into vascular compartment in healthy subjects","volume":"263","author":"Maclouf J","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1990.tb19458.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200412-1693OC"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.03.049"},{"key":"e_1_2_1_28_2","first-page":"1132","article-title":"Clinical evaluation of urinary leukotriene e4 levels in children with respiratory syncytial virus infection","volume":"52","author":"Takahashi Y","year":"2003","journal-title":"Arerugi"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00021202"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05104-6"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00414.2001"},{"key":"e_1_2_1_32_2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/01.inf.0000053888.67311.1d","article-title":"The contribution of neuro\u2010immune mechanisms to airway inflammation and remodeling during and after respiratory syncytial virus infection","volume":"22","author":"Piedimonte G","year":"2003","journal-title":"Pediatr Infect Dis J"},{"key":"e_1_2_1_33_2","first-page":"26","article-title":"The association between respiratory syncytial virus infection and reactive airway disease","volume":"96","author":"Piedimonte G","year":"2002","journal-title":"Respir Med [Suppl]"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200207-747OC"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.169.4.952"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20285","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.20285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T11:06:55Z","timestamp":1697627215000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.20285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,16]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["10.1002\/ppul.20285"],"URL":"https:\/\/doi.org\/10.1002\/ppul.20285","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,16]]}}}