{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:09:43Z","timestamp":1790896183864,"version":"4.1.0"},"reference-count":129,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,15]],"date-time":"2005-11-15T00:00:00Z","timestamp":1132012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intestinal malabsorption is severe and of early onset in virtually all people who have cystic fibrosis. The main cause is deficiency of pancreatic enzymes. Bicarbonate deficiency, abnormal bile salts, mucosal transport problems, motility differences, and anatomical structural changes are other contributory factors. Effective treatment should allow a normal to high\u2010fat diet to be taken, control symptoms, correct malabsorption, and achieve a normal nutritional state and growth. Appropriate pancreatic enzyme replacement therapy will achieve normal or near\u2010normal absorption in most people with cystic fibrosis. Early identification and treatment of intestinal malabsorption is critical to achieving optimal nutritional status. The occurrence of fibrosing colonopathy in a few patients on very high doses of those enzymes which have the copolymer Eudragit L30 D55 in their covering resulted in guidelines in the UK to avoid doses equivalent to more than 10,000 IU lipase per kg per day, and also to avoid preparations containing this copolymer in children and adolescents. For patients not responding to 10,000 IU lipase per kg per day review of adherence to treatment, change of enzyme preparation, variation in time of administration, and reduction in gastric acid may improve absorption. The importance of early investigation to exclude other gastrointestinal disorders as a cause of the patient's symptoms, rather than merely increasing the dose of enzymes, is stressed. With modern pancreatic enzymes in doses up to or only slightly in excess of 10,000 IU lipase per kg per day, adequate control of gastrointestinal symptoms and absorption can be achieved, and a normal nutritional state and growth rate maintained in most people with cystic fibrosis. Pediatr Pulmonol. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20286","type":"journal-article","created":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T02:48:25Z","timestamp":1132195705000},"page":"35-49","source":"Crossref","is-referenced-by-count":99,"title":["Diagnosis and Treatment of Intestinal Malabsorption in Cystic Fibrosis"],"prefix":"10.1002","volume":"41","author":[{"given":"James M.","family":"Littlewood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan P.","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Conway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82478-3"},{"key":"e_1_2_1_3_2","first-page":"1178","article-title":"Genetic determination of exocrine pancreatic function in cystic fibrosis","volume":"50","author":"Kristidis P","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.25.5.500"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001574-198910000-00017"},{"key":"e_1_2_1_6_2","first-page":"2","article-title":"Pathophysiology of the exocrine pancreas in cystic fibrosis","volume":"82","author":"Durie PR","year":"1989","journal-title":"J R Soc Med [Suppl 16]"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528809090233"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536423"},{"key":"e_1_2_1_9_2","first-page":"63","article-title":"Simultaneously measured duodenal and gastric pH in patients with cystic fibrosis: effect of omeprazole","volume":"54","author":"Geus WP","year":"1999","journal-title":"Neth J Med [Suppl]"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199809000-00005"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197712152972401"},{"key":"e_1_2_1_12_2","first-page":"110","article-title":"Relationship between intestinal function and chloride secretion in patients with cystic fibrosis","volume":"41","author":"Sinaasappel M","year":"1992","journal-title":"Neth J Med"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/69.1.127"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2003.08.002"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.6.585"},{"key":"e_1_2_1_16_2","first-page":"37","article-title":"Stable isotope studies of pancreatic enzyme release in vivo","volume":"72","author":"Seal S","year":"1996","journal-title":"Postgrad Med J [Suppl]"},{"key":"e_1_2_1_17_2","first-page":"241","article-title":"Pathology of cystic fibrosis. Review of the literature and comparison with 146 autopsied cases","volume":"2","author":"Oppenheimer EH","year":"1975","journal-title":"Perspect Pediatr Pathol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01300190"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.66.4.495"},{"key":"e_1_2_1_20_2","first-page":"181","volume-title":"Clinical ecology of cystic fibrosis","author":"Littlewood JM","year":"1993"},{"key":"e_1_2_1_21_2","first-page":"7","article-title":"Abdominal pain in cystic fibrosis","volume":"88","author":"Littlewood JM","year":"1995","journal-title":"J R Soc Med"},{"key":"e_1_2_1_22_2","first-page":"388","volume-title":"Consensus in clinical nutrition","author":"Littlewood JM","year":"1994"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128072-200002030-00005"},{"key":"e_1_2_1_24_2","unstructured":"Nutritional management of cystic fibrosis. Report of the UK Cystic Fibrosis Trust Nutrition Working Group. Cystic Fibrosis Trust; London2002."},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(02)00032-2"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.7.785"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.35.5.547"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199701000-00013"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050709"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(200003)29:3<172::AID-PPUL3>3.0.CO;2-1"},{"key":"e_1_2_1_31_2","first-page":"500","article-title":"Usefulness of faecal elastase\u20101 assay in monitoring pancreatic function in childhood coeliac disease","volume":"30","author":"Carroccio A","year":"1998","journal-title":"Dig Liver Dis"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.04.049"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200304000-00010"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.124829"},{"key":"e_1_2_1_35_2","first-page":"13","article-title":"Gastrointestinal complications in cystic fibrosis","volume":"85","author":"Littlewood JM","year":"1992","journal-title":"J R Soc Med [Suppl]"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)57092-7"},{"key":"e_1_2_1_37_2","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1542\/peds.46.5.690","article-title":"Faecal fat and nitrogen in healthy children and in children with malabsorption and maldigestion","volume":"46","author":"Schmerling DH","year":"1970","journal-title":"Pediatrics"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.1.99"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199410000-00007"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1997.tb08914.x"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200208000-00018"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.4.349"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2003.03310.x"},{"key":"e_1_2_1_44_2","first-page":"363","article-title":"Fecal fat balance and the 13C mixed triglyceride breath test: diagnostic precision as determined in repeated studies in patients with cystic fibrosis","volume":"17","author":"Swart GR","year":"1998","journal-title":"Pediatr Pulmonol [Suppl]"},{"key":"e_1_2_1_45_2","unstructured":"Standards for the clinical care of children and adults with cystic fibrosis in the UK. UK Cystic Fibrosis Trust Clinical Standards and Accreditation Group. Cystic Fibrosis Trust; London2001."},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90817-6"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70153-2"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91860-4"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705013361803"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91346-7"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.79.4.339"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1557(199709\/10)6:5<347::AID-PDS305>3.0.CO;2-2"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1557(199910\/11)8:6<377::AID-PDS448>3.0.CO;2-C"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.74.5.466"},{"key":"e_1_2_1_55_2","first-page":"56","article-title":"Management of malabsorption in cystic fibrosis: influence of recent developments on clinical practice","volume":"72","author":"Littlewood JM","year":"1996","journal-title":"Postgrad Med J [Suppl]"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1177\/014107689909237S08"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199902000-00020"},{"key":"e_1_2_1_58_2","first-page":"71","article-title":"Selective use of Creon 40,000 in a specialist adult CF unit","volume":"3","author":"Hartley R","year":"2004","journal-title":"J Cystic Fibrosis"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06593-X"},{"key":"e_1_2_1_60_2","unstructured":"Report of the Pancreatic Enzymes Working Party Medicine Control Agency Committee on Safety of Medicines May 1995."},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-0673.1996.00433.x"},{"key":"e_1_2_1_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90669-5"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.80.2.149"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-277X.1998.00130.x"},{"key":"e_1_2_1_65_2","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0002-8223(21)00735-5","article-title":"Effectiveness of enteric coated pancreatic enzymes given before meals in reducing steatorrhea in children with cystic fibrosis","volume":"92","author":"Brady MS","year":"1992","journal-title":"J Am Diet Assoc"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.1177\/014107689809134S02"},{"key":"e_1_2_1_67_2","first-page":"1060","article-title":"Comparison of effectiveness of pancreatic enzyme preparations in cystic fibrosis","volume":"136","author":"Mischler EH","year":"1982","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_68_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.6.564"},{"key":"e_1_2_1_69_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.78.4.377"},{"key":"e_1_2_1_70_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.1.35"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200211000-00004"},{"key":"e_1_2_1_72_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.1999.00363.x"},{"key":"e_1_2_1_73_2","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200211000-00010"},{"key":"e_1_2_1_74_2","unstructured":"PatchellC MacDonaldA WellerPW.Pancreatic enzymes with enteral feeds. How should we give them?European Cystic Fibrosis Conference. Abstracts of Meeting of European Cystic Fibrosis Society Berlin.1998. p104."},{"key":"e_1_2_1_75_2","unstructured":"KerrinD WolfeS BrownleeK ConwayS.Overnight tube feeds\u2014are enzymes necessary?XIII International Cystic Fibrosis Congress. Abstracts of Meeting of European Cystic Fibrosis Society Stockholm.2000. p119."},{"key":"e_1_2_1_76_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000110522.78194.5B"},{"key":"e_1_2_1_77_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7170.1401"},{"key":"e_1_2_1_78_2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1542\/peds.78.3.473","article-title":"Constipation and meconium ileus equivalent in patients with cystic fibrosis","volume":"78","author":"Rubinstein S","year":"1986","journal-title":"Pediatrics"},{"key":"e_1_2_1_79_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199010000-00012"},{"key":"e_1_2_1_80_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.61.11.1128"},{"key":"e_1_2_1_81_2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1542\/peds.83.5.727","article-title":"Lavage treatment of distal intestinal obstruction syndrome in children with cystic fibrosis","volume":"83","author":"Koletzko S","year":"1989","journal-title":"Pediatrics"},{"key":"e_1_2_1_82_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.66.11.1339"},{"key":"e_1_2_1_83_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.78.1.44"},{"key":"e_1_2_1_84_2","doi-asserted-by":"publisher","DOI":"10.1177\/014107689809100103"},{"key":"e_1_2_1_85_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.9.1251"},{"key":"e_1_2_1_86_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199011000-00002"},{"key":"e_1_2_1_87_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02087437"},{"key":"e_1_2_1_88_2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF02931323","article-title":"Relapsing pancreatitis as an initial manifestation of cystic fibrosis in young man with cystic fibrosis","volume":"4","author":"Gross V","year":"1989","journal-title":"Int J Pancreatol"},{"key":"e_1_2_1_89_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37042"},{"key":"e_1_2_1_90_2","first-page":"31","article-title":"Chronic pancreatitis and cystic fibrosis","volume":"52","author":"Witt H","year":"2003","journal-title":"Gut [Suppl]"},{"key":"e_1_2_1_91_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200004000-00015"},{"key":"e_1_2_1_92_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1989.tb11146.x"},{"key":"e_1_2_1_93_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007159"},{"key":"e_1_2_1_94_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.1.e13"},{"key":"e_1_2_1_95_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.1997.tb01017.x"},{"key":"e_1_2_1_96_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200012000-00006"},{"key":"e_1_2_1_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80609-5"},{"key":"e_1_2_1_98_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.9.778"},{"key":"e_1_2_1_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91276-9"},{"key":"e_1_2_1_100_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296725"},{"key":"e_1_2_1_101_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1985.tb10930.x"},{"key":"e_1_2_1_102_2","first-page":"355","article-title":"Does the addition of bicarbonate to an enzyme microsphere preparation improve efficacy?","volume":"17","author":"Kalnins D","year":"1998","journal-title":"Pediatr Pulmonol [Suppl]"},{"key":"e_1_2_1_103_2","first-page":"CD003424","article-title":"Drug therapies for reducing gastric acidity in people with cystic fibrosis","volume":"2","author":"Ng SM","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_1_104_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529009093147"},{"key":"e_1_2_1_105_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296765"},{"key":"e_1_2_1_106_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-003-1309-5"},{"key":"e_1_2_1_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-2977(99)90227-9"},{"key":"e_1_2_1_108_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1991.02160120069022"},{"key":"e_1_2_1_109_2","first-page":"417","article-title":"Hyperuricosuria in cystic fibrosis patients treated with pancreatic enzyme supplements","volume":"16","author":"Sack J","year":"1980","journal-title":"Isr J Med Sci"},{"key":"e_1_2_1_110_2","first-page":"171","article-title":"Uric acid serum concentrations in CF children after pancreatic enzyme supplementation","volume":"28","author":"Wiersbitzky S","year":"1989","journal-title":"Padiatr Grenzgeb"},{"key":"e_1_2_1_111_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199109000-00009"},{"key":"e_1_2_1_112_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.77.1.66"},{"key":"e_1_2_1_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91775-2"},{"key":"e_1_2_1_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(77)90174-9"},{"key":"e_1_2_1_115_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.42.7.533"},{"key":"e_1_2_1_116_2","first-page":"109","article-title":"Comparison of two pancreatic enzyme supplements in patients with cystic fibrosis","volume":"7","author":"George DE","year":"1990","journal-title":"Adv Ther"},{"key":"e_1_2_1_117_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950100208"},{"key":"e_1_2_1_118_2","first-page":"107","article-title":"A comparison between two pancreatin microsphere preparations in cystic fibrosis","volume":"105","author":"Elliott RB","year":"1992","journal-title":"N Z Med J"},{"key":"e_1_2_1_119_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199408000-00009"},{"key":"e_1_2_1_120_2","first-page":"358","article-title":"Double\u2010blind, cross\u2010over study to prove the equivalence of Creon 10,000 minimicrospheres vs. Creon 8000 microspheres in patients with cystic fibrosis","volume":"17","author":"Sinaasappel M","year":"1998","journal-title":"Pediatr Pulmonol [Suppl]"},{"key":"e_1_2_1_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(02)00103-0"},{"key":"e_1_2_1_122_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02244.x"},{"key":"e_1_2_1_123_2","first-page":"339","article-title":"Ultrase MT12 and Ultrase MT20 in the treatment of exocrine pancreatic insufficiency in cystic fibrosis: safety and efficacy","volume":"27","author":"Konstan M","year":"2004","journal-title":"Pediatr Pulmonol [Suppl]"},{"key":"e_1_2_1_124_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1992.tb00569.x"},{"key":"e_1_2_1_125_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03259592"},{"key":"e_1_2_1_126_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.2.227"},{"key":"e_1_2_1_127_2","first-page":"236","article-title":"Comparison of a high strength pancreatic enzyme preparation and a standard strength preparation in cystic fibrosis","volume":"12","author":"Friesen C","year":"1995","journal-title":"Adv Ther"},{"key":"e_1_2_1_128_2","first-page":"220","article-title":"Evaluation of Creon 25,000 compared to standard lipase pancreatic enzyme supplementation in cystic fibrosis patients","volume":"32","author":"Taylor CJ","year":"1996","journal-title":"Isr J Med Sci"},{"key":"e_1_2_1_129_2","doi-asserted-by":"publisher","DOI":"10.1002\/jppr1998283160"},{"key":"e_1_2_1_130_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-76097-6_7"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20286","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.20286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:55:18Z","timestamp":1696622118000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.20286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,15]]},"references-count":129,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1002\/ppul.20286"],"URL":"https:\/\/doi.org\/10.1002\/ppul.20286","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,15]]}}}