{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:38:19Z","timestamp":1790120299214,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,10,14]],"date-time":"2005-10-14T00:00:00Z","timestamp":1129248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of dexamethasone on in vitro airway reactivity associated with lung inflammation were investigated in rabbits with meconium aspiration. Oxygen\u2010ventilated adult rabbits received an intratracheal bolus of 4 ml\/kg body weight of saline (Sal, n\u2009=\u20094) or human meconium (25 mg\/ml). Thirty minutes later, meconium\u2010instilled animals intravenously received 0.5 mg\/kg of dexamethasone (Dexa, n\u2009=\u20096), or were left without treatment (Meco, n\u2009=\u20095). The animals were ventilated for a further 5 hr and then sacrificed. The left lungs were lavaged with saline, and the white blood cell (WBC) count was estimated. Tracheal and right\u2010lung tissue strips were placed into organ chambers with Krebs\u2010Henseleit solution. Cumulative doses of histamine (10<jats:sup>\u22128<\/jats:sup>\u201310<jats:sup>\u22123<\/jats:sup> mol\/l) and acetylcholine (10<jats:sup>\u22128<\/jats:sup>\u201310<jats:sup>\u22123<\/jats:sup> mol\/l) were added to the chambers, and recordings of contractions were made after a 30\u2010min loading phase with a tension of 4 grams, and another 30\u2010min adaptation phase with a tension of 2 g. Tracheal smooth muscle in vitro reactivity to histamine was higher in the Meco than in the Sal group, and dexamethasone decreased the reactivity compared to the Meco group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Lung tissue in vitro reactivity to histamine was slightly higher in the Meco than in the Sal group (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05), and dexamethasone decreased the reactivity compared to both the Meco and Sal groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). No between\u2010group differences were observed in tracheal or lung in vitro reactivity to acetylcholine (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). In the Meco group, blood WBC (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05) and neutrophil (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) counts were lower than in the Sal and Dexa groups. Lung neutrophils and eosinophils were higher in both the Meco and Dexa groups than in the Sal group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Dexamethasone decreased neutrophils (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) compared to the Meco group. Meconium\u2010induced airway hyperreactivity to histamine and lung inflammation were alleviated by dexamethasone. Pediatr Pulmonol. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20330","type":"journal-article","created":{"date-parts":[[2005,10,14]],"date-time":"2005-10-14T21:46:25Z","timestamp":1129326385000},"page":"55-60","source":"Crossref","is-referenced-by-count":26,"title":["Dexamethasone Alleviates Meconium\u2010Induced Airway Hyperresponsiveness and Lung Inflammation in 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