{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:01:43Z","timestamp":1782961303209,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,2,13]],"date-time":"2006-02-13T00:00:00Z","timestamp":1139788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ventilation with an inappropriate tidal volume (Vt) triggers lung inflammation, an important predisposing factor of bronchopulmonary dysplasia. It still remains uncertain what the appropriate starting target Vt should be during the acute phase of respiratory distress syndrome (RDS). Our aim was to evaluate lung inflammation in preterm infants undergoing synchronized intermittent positive\u2010pressure ventilation (SIPPV) with two different tidal volumes Vt during the acute phase of RDS. Thirty preterm infants (gestational age, 25\u201332 weeks) with acute RDS were randomly assigned to be ventilated with Vt\u2009=\u20095ml\/kg (n\u2009=\u200915) or Vt\u2009=\u20093 ml\/kg (n\u2009=\u200915). Proinflammatory cytokines (interleukin\u20106 (IL\u20106), interleukin\u20108 (IL\u20108), and tumor necrosis factor (TNF)\u2010\u03b1) were determined in the tracheal aspirate on days 1, 3, and 7 of life. IL\u20108 and TNF\u2010\u03b1 levels collected on day 7 were significantly higher (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and mechanical ventilation lasted longer in the group with Vt\u2009=\u20093 ml\/kg (16.8\u2009\u00b1\u20094 vs. 9.2\u2009\u00b1\u20094 days; <jats:italic>P<\/jats:italic>\u2009=\u20090.05). In conclusion, our data show significantly higher lung inflammation in preterm infants ventilated with Vt\u2009=\u20093 ml\/kg, suggesting a role for Vt\u2009=\u20095 ml\/kg in reducing both inflammatory response during the acute phase of RDS and the length of ventilation. Whether the use of this starting Vt prevents bronchopulmonary dysplasia requires further study. Pediatr Pulmonol. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20363","type":"journal-article","created":{"date-parts":[[2006,2,13]],"date-time":"2006-02-13T23:46:51Z","timestamp":1139874411000},"page":"357-363","source":"Crossref","is-referenced-by-count":89,"title":["Lung inflammation in preterm infants with respiratory distress syndrome: Effects of ventilation with different tidal volumes"],"prefix":"10.1002","volume":"41","author":[{"given":"Gianluca","family":"Lista","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Castoldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Reali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Reggiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Compagnoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200212000-00025"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000063608"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-2756(02)00190-2"},{"key":"e_1_2_1_5_2","first-page":"373","article-title":"Normal and abnormal alveolar development","volume":"20","author":"Delacourt C","year":"2003","journal-title":"Rev Mal Respir"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2004.05.003"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.1.112"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.suppl_1.9S-a"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.3.529"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20063"},{"key":"e_1_2_1_11_2","first-page":"453","article-title":"Il \u201cvolume garantito\u201d (VG) in corso di pressure support ventilation (PSV) riduce il rischio di barotrauma in pretermine con sindrome respiratoria grave (RDS)","volume":"71","author":"Lista G","year":"2000","journal-title":"Acta Biomed Ateneo Parmense"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10458"},{"key":"e_1_2_1_13_2","first-page":"323","article-title":"Influence of tidal volume on the compliance of the respiratory system in mechanically ventilated newborn infants","volume":"101","author":"Popow C","year":"1989","journal-title":"Wien Klin Wochenschr"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20063"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199809000-00011"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199408000-00017"},{"key":"e_1_2_1_18_2","first-page":"214","volume-title":"Fetus and neonate. 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