{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T22:45:38Z","timestamp":1773355538028,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,2,24]],"date-time":"2006-02-24T00:00:00Z","timestamp":1140739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although frequently used to treat status asthmaticus in children, intravenous (IV) terbutaline has not been shown to decrease hospital length of stay (LOS). We theorized that this lack of demonstrable benefit resulted from variations in dosing and titration, rather than the drug per se, and that intensive care unit (ICU) LOS would be shortened by the administration of terbutaline according to a protocol incorporating a quantitative assessment of severity of illness. We prospectively treated 20 consecutive children with status asthmaticus with IV terbutaline according to a protocol that titrated the dose based on a clinical asthma score, the Modified Pulmonary Index Score (MPIS). Data were compared to a historic cohort of the previous 20 consecutive ICU patients with status asthmaticus who were treated with IV terbutaline prior to initiation of the protocol. Patients who received terbutaline by standardized protocol had significantly shorter ICU LOS (3.5\u2009\u00b1\u20091.1 vs. 5.0\u2009\u00b1\u20092.0 days, <jats:italic>P<\/jats:italic>\u2009=\u20090.01), shorter hospital LOS (5.5\u2009\u00b1\u20091.3 vs. 8.3\u2009\u00b1\u20092.7 days, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), and reduced hospital charges ($19,298\u2009\u00b1\u2009$10,516 vs. $26,528\u2009\u00b1\u2009$12,328, <jats:italic>P<\/jats:italic>\u2009=\u20090.04). The method of administration of IV terbutaline significantly influenced ICU length of stay and hospital charges. Pediatr Pulmonol. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20394","type":"journal-article","created":{"date-parts":[[2006,2,24]],"date-time":"2006-02-24T19:17:01Z","timestamp":1140808621000},"page":"350-356","source":"Crossref","is-referenced-by-count":19,"title":["Protocol\u2010based titration of intravenous terbutaline decreases length of stay in pediatric status asthmaticus"],"prefix":"10.1002","volume":"41","author":[{"given":"Christopher L.","family":"Carroll","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig M.","family":"Schramm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(02)00033-0"},{"key":"e_1_2_1_3_2","first-page":"1145","article-title":"Acute asthma in the pediatric emergency department","volume":"46","author":"Smith SR","year":"1999","journal-title":"Emerg Med Clin North Am"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.48.2_Suppl.S1"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-199804000-00004"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.6.1913"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.106567"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199810000-00033"},{"key":"e_1_2_1_9_2","first-page":"213","article-title":"Continuous intravenous terbutaline infusions for adult patients with status asthmaticus","volume":"64","author":"O'Connell MB","year":"1990","journal-title":"Ann Allergy"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80805-4"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.106.6.1654"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.129966"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1542\/peds.88.6.1180","article-title":"Cardiotoxicity during treatment of severe childhood asthma","volume":"88","author":"Maguire JF","year":"1991","journal-title":"Pediatrics"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60987-8"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199605000-00004"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.6_suppl.454S"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.1.236"},{"key":"e_1_2_1_18_2","first-page":"772","article-title":"Weaning children from mechanical ventilation: a prospective randomized trial of protocol\u2010directed versus physician directed weaning","volume":"46","author":"Schultz TR","year":"2001","journal-title":"Respir Care"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.133.5.483"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.2.459"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199712000-00011"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0704(05)70192-5"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00063110-200309000-00012"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20394","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.20394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T16:34:34Z","timestamp":1696696474000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.20394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,24]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1002\/ppul.20394"],"URL":"https:\/\/doi.org\/10.1002\/ppul.20394","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,24]]}}}