{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T15:57:54Z","timestamp":1732031874642},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,3,17]],"date-time":"2006-03-17T00:00:00Z","timestamp":1142553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many infants with a repaired esophageal atresia (EA) undergo fundoplication, aortopexy, or glossopexy because the mechanisms most responsible for airway obstruction and\/or apparent life\u2010threatening event (AO\/ALTE) syndrome are considered to be gastroesophageal reflux (GER), tracheal compression (TC), or obstructive apnea, respectively. In the present study, we investigated whether these mechanisms are independent or interrelated. We developed a database of 120 consecutive patients with EA treated by the senior author between 1967\u20132002. We studied the clinical manifestations of patients with a cervical esophagostomy and\/or blind lower esophageal stump, which ruled out TC and\/or proximal esophageal GER as a mechanism for AO\/ALTE. Of 25 neonates who underwent section\/ligation of lower tracheo\u2010esophageal fistula and\/or feeding gastrostomy, 10 critically ill neonates died. Of 15 survivors, 9 infants had a feeding gastrostomy without an esophagostomy. Of these, 6 infants presented one or more episodes of AO, and 8 presented ALTE with or without AO. Subsequently, 5 of the 9 infants underwent an esophagostomy. Eventually, 11 infants had a feeding gastrostomy with an esophagostomy. Of the latter, 5 infants presented one or more episodes of AO, and 6 presented ALTE without AO. In conclusion, oral feeding, proximal esophageal GER, and TC are not essential for AO\/ALTE syndrome to occur. They are probably factors which offer evidence of an underlying problem with control of upper airway patency. Pediatr Pulmonol. 2006; 41:488\u2013493. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20408","type":"journal-article","created":{"date-parts":[[2006,3,17]],"date-time":"2006-03-17T20:46:54Z","timestamp":1142628414000},"page":"488-493","source":"Crossref","is-referenced-by-count":17,"title":["Pathogenesis of apparent life\u2010threatening events in infants with esophageal 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