{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:39:58Z","timestamp":1757705998386},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our aim was to determine whether antenatal corticosteroids improve perinatal adaptation of the pulmonary circulation in lambs with lung hypoplasia (LH). LH was induced in 12 ovine fetuses between 105 and 140 days gestation (term \u223c147 days); in 6 of these the ewe was given a single dose of betamethasone (11.4 mg im) 24 hr before delivery (LH\u2009+\u2009B). All lambs, including a control group (n\u2009=\u20096), were delivered at \u223c140 days and ventilated for 2 hr during which arterial pressures, pulmonary blood flow (PBF), and ventilating pressure and flow were recorded. During ventilation, respiratory system compliance was lower in both LH\u2009+\u2009B and LH groups than in controls. Pulmonary vascular resistance (PVR) was lower in LH\u2009+\u2009B lambs than in LH lambs and similar to controls; PBF was reduced in LH lambs but was restored to control levels by betamethasone. The mean density of small arteries of LH\u2009+\u2009B lambs was similar to that of LH lambs (<jats:italic>P<\/jats:italic>\u2009=\u20090.06) and lower than in controls; the thickness of the media of small pulmonary arteries from LH\u2009+\u2009B lambs was similar to that in LH lambs and thicker than in controls. VEGF mRNA levels were not different between groups. PDGF mRNA levels in LH\u2009+\u2009B lambs were higher than in LH lambs; a similar trend (<jats:italic>P<\/jats:italic>\u2009=\u20090.06) was seen for PECAM\u20101. SP\u2010C mRNA levels were greater in both LH and LH\u2009+\u2009B lambs than in controls. Effects of betamethasone were greater on indices of pulmonary circulation than ventilation. We conclude that a single dose of maternal betamethasone 24 hr prior to birth has significant favorable effects on the postnatal adaptation of the pulmonary circulation in lambs with LH. Pediatr Pulmonol. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20453","type":"journal-article","created":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T18:12:17Z","timestamp":1153246337000},"page":"844-854","source":"Crossref","is-referenced-by-count":9,"title":["Effects of antenatal corticosteroid treatment on pulmonary ventilation and circulation in neonatal lambs with hypoplastic lungs"],"prefix":"10.1002","volume":"41","author":[{"given":"Keiji","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart B.","family":"Hooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan J.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan 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