{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:44:38Z","timestamp":1792449878287,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T00:00:00Z","timestamp":1153872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pre\u2010school children are frequently affected by wheezing illness, with substantial influences on their health\u2010related quality of life (HRQL). The Infant\/Toddler Quality of Life Questionnaire (ITQOL) is the only generic health status measure for children aged 2 months up to 5 years. In this present study we evaluated the impact of wheezing illness in pre\u2010school children on the HRQL, using the ITQOL. A questionnaire including the ITQOL and ISAAC questions on frequency and severity of respiratory complaints were sent to parents of patients aged 6 months\u20135 years visiting the outpatient department with wheezing illness. Scale scores of ITQOL of the included children were compared with general population scores. Using multivariate analysis, the influence of general and clinical characteristics on ITQOL scale scores was evaluated. Results are based on 138 children, 59% male, mean age 34 months. Children with wheezing illness scored differently to the general population sample on 8 of the 11 ITQOL scales. Age, comorbidity and employment of the respondent affected scales on child's physical and emotional functioning and parental functioning. Severity of dyspnoea and wheezing, presence of cough, corticosteroid use, and number of GP visits negatively affected scales on the child's physical and emotional functioning. In conclusion, the HRQL as measured by the ITQOL was lower in a group of Dutch pre\u2010school children with wheezing illness compared to a general population sample. The scale scores were sensitive to age, co morbidity, socio\u2010economic situation, and disease severity. Pediatr Pulmonol. 2006, 41:993\u20131000. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20486","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T23:46:25Z","timestamp":1153957585000},"page":"993-1000","source":"Crossref","is-referenced-by-count":35,"title":["Health\u2010related quality of life of pre\u2010school children with wheezing illness"],"prefix":"10.1002","volume":"41","author":[{"given":"R.","family":"Oostenbrink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.M.","family":"Jansingh\u2010Piepers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Raat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nuijsink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Landgraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.L.","family":"Essink\u2010Bot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.A.","family":"Moll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,26]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"3s","article-title":"Types of asthma and wheezing","volume":"12","author":"Martinez FD","year":"1998","journal-title":"Eur Respir J"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"},{"key":"e_1_2_1_4_2","first-page":"429","article-title":"Management of asthma in pre\u2010school children","volume":"42","author":"McCarthy TP","year":"1992","journal-title":"Br J General Practice"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.2.e1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.77.4.347"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jech.50.4.391"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199916060-00002"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008801802877"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023233308653"},{"key":"e_1_2_1_11_2","volume-title":"The Infant\/Toddler Quality of Life Questionnaire: conceptual framework, logic, content and preliminary psychometric results","author":"Landgraf JM","year":"1994"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1477-7525-1-81","article-title":"Health related quality of life in 3 and 4 year old children and their parents: preliminary findings about a new questionnaire","volume":"1","author":"Klassen AF","year":"2003","journal-title":"Health Qual Life Outcomes"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(00)70007-9"},{"key":"e_1_2_1_14_2","volume-title":"The Child Health Questionnaire (CHQ): a user's manual 2nd printing","author":"Landgraf JM","year":"1999"},{"key":"e_1_2_1_15_2","first-page":"5","article-title":"Measuring pediatric outcomes in applied clinical settings: an update about the Child Health Questionnaire (CHQ)","volume":"23","author":"Landgraf JM","year":"1999","journal-title":"Qual Life Newlett MAPI Res Inst"},{"key":"e_1_2_1_16_2","first-page":"S1","article-title":"Cross\u2010cultural adaptation and psychometric evaluation of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Helath Questionnaire (CHQ) in 32 countries. Review of the general methodology","volume":"19","author":"Ruperto N","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00411-5"},{"key":"e_1_2_1_18_2","first-page":"S111","article-title":"The Dutch version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ)","volume":"19","author":"Wulffraat N","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_19_2","first-page":"S20","article-title":"The Belgian\u2010Flemish version of the Childhood Helath Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ)","volume":"19","author":"Joos R","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/08870449708406744"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016393311799"},{"key":"e_1_2_1_22_2","volume-title":"Constitution of the World Health Organization. WHO Basic Documents","author":"Organization WH","year":"1948"},{"key":"e_1_2_1_23_2","volume-title":"The first twelve months of life: your baby's growth month by months","author":"Caplan F","year":"1975"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","unstructured":"RaatH LandgrafJM OostenbrinkR MollHA Essink\u2010BotML.Reliability and validity of the Infant and Toddler Quality of Life Questionnaire (ITQOL) in a General Population\u2010 and Respiratory Disease Sample. Under review.2006.","DOI":"10.1007\/s11136-006-9134-8"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-200106000-00003"},{"key":"e_1_2_1_26_2","unstructured":"CBO.Consensus astma bij kinderen. Utrecht 1992."},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(93)90142-N"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb06930.x"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1525\/ae.2004.31.4.475"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.77.4.350"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6862.1145"},{"key":"e_1_2_1_32_2","first-page":"2680","article-title":"The Dutch RAND general health rating index for children: a questionnaire measuring general health of children","volume":"142","author":"Post MWM","year":"1998","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.2001067"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008878031176"},{"key":"e_1_2_1_35_2","first-page":"785","volume-title":"Quality of life and pharmacoeconomics in clinical trials","author":"Rosenbaum PL","year":"1996"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7299.1417"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20486","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.20486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T21:01:46Z","timestamp":1695675706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.20486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,26]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1002\/ppul.20486"],"URL":"https:\/\/doi.org\/10.1002\/ppul.20486","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,26]]}}}