{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:23:56Z","timestamp":1782231836235,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,1,23]],"date-time":"2007-01-23T00:00:00Z","timestamp":1169510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The contribution of respiratory viral infections to the onset of asthma and atopy is controversial. In \u201chigh risk\u201d children (n\u2009=\u2009455) born into asthmatic\/atopic families, we determined the relationship of exposures to common respiratory viruses and concomitant respiratory symptoms, and to subsequent possible asthma and atopy at ages 1 and 2 years. Frozen nasal specimens, obtained when children were 2 weeks, 4, 8, and 12 months old, underwent reverse transcription\u2010polymerase chain reaction (RT\u2010PCR) testing for parainfluenza virus (PIV), respiratory syncytial virus (RSV), and picornavirus (rhinovirus\/enterovirus). Odds ratios of viral RT\u2010PCR results to respiratory symptoms (\u201ccold,\u201d rhinitis, cough, wheezing) and to possible asthma or atopy at 1 and 2 years of age were calculated. Positive viral RT\u2010PCR was associated with increased odds of \u201ccold\u201d and cough; PIV and picornavirus were associated with rhinitis, and RSV was associated with wheezing. PIV was associated with increased odds of atopy at 1 year of age in the control group; PIV and RSV were associated with possible asthma at 2 years of age. We conclude that in high\u2010risk children, viral exposures documented by RT\u2010PCR are associated with respiratory symptoms, and exposures to PIV and RSV during the first year of life are associated with the initial onset of possible asthma. Pediatr Pulmonol. 2007; 42:290\u2013297. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20578","type":"journal-article","created":{"date-parts":[[2007,1,23]],"date-time":"2007-01-23T20:13:33Z","timestamp":1169583213000},"page":"290-297","source":"Crossref","is-referenced-by-count":56,"title":["Relationship of early childhood viral exposures to respiratory symptoms, onset of possible asthma and atopy in high risk children: The Canadian asthma primary prevention study"],"prefix":"10.1002","volume":"42","author":[{"given":"Kathy K.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Hegele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jure","family":"Manfreda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Wooldrage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan B.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Dimich\u2010Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade T.A.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira","family":"Chan\u2010Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000162308.89857.6c"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000108196.46134.a6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.10.033"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-730OC"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1542\/peds.109.SE1.357","article-title":"Defining asthma in the preschool\u2010aged child","volume":"109","author":"Strunk RC","year":"2002","journal-title":"Pediatrics"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.9912111"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(79)90106-4"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200504-044AW"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000168747.94999.aa"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200206000-00010"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000144660.53024.64"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1992.tb03094.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe058036"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.154.7.657"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.01.754"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1128\/jcm.34.1.140-143.1996","article-title":"Diagnosis of viral respiratory tract infections in children by using a reverse transcription\u2010polymerase chain reaction (RT\u2010PCR) panel","volume":"34","author":"Gilbert LL","year":"1996","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.114479"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1128\/jcm.28.4.738-741.1990","article-title":"Rapid detection of respiratory syncytial virus in nasopharyngeal specimens obtained with the Rhinoprobe scraper","volume":"28","author":"Jalowayski AA","year":"1990","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/02770909909087298"},{"key":"e_1_2_1_22_2","volume-title":"Stata Statistical Software: Release 6.0","author":"Stata Corp","year":"1999"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000207395.80657.cf"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20243"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.3.9801052"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00233.x"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000053889.39392.a7"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.06.024"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20578","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.20578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T18:34:17Z","timestamp":1700073257000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.20578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,29]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1002\/ppul.20578"],"URL":"https:\/\/doi.org\/10.1002\/ppul.20578","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,29]]}}}