{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T13:28:17Z","timestamp":1769434097586,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T00:00:00Z","timestamp":1173830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Congenital diaphragmatic hernia (CDH) is accompanied by pulmonary hypoplasia and structural abnormalities of the pulmonary vascular bed. It is unknown whether pulmonary function, exercise capacity, and gas exchange during exercise are impaired in adult CDH survivors. The objective of this study was to assess the long\u2010term pulmonary function, exercise capacity, and gas exchange during exercise and relate these findings with quality of life. Of the 23 patients eligible for this study, 12 adult CDH survivors (mean age, 24.3\u2009\u00b1\u20094.1 years) with high\u2010risk CDH agreed to participate. Pulmonary function tests, diffusion capacity, and a cardiopulmonary exercise test (CPET) were performed. The FEV1 (mean z\u2010score\u2009\u00b1\u2009SD; \u22121.30\u2009\u00b1\u20091.37), FEF25\u201375% (\u22121.49\u2009\u00b1\u20091.14), and the KCO (\u22121.03\u2009\u00b1\u20091.24) were found to be lower in CDH survivors. The RV\/TLC ratio (28.2%\u2009\u00b1\u20095.0%) was found to be higher. Despite these abnormalities, percent predicted work load (102%\u2009\u00b1\u200917.2%) and percent predicted maximal oxygen uptake (90.8%\u2009\u00b1\u200918.9%) were normal in most of the patients. The quality of life of CDH survivors, assessed with the SF\u201036 questionnaire, is comparable to the general population. Comparison of participants to non\u2010participants did not reveal significant differences in clinical characteristics. In this first study assessing pulmonary function in adult survivors of CDH, mild airway obstruction was observed in most of the patients together with a slightly reduced diffusion capacity for CO. Exercise capacity and gas exchange parameters were normal in this group, indicating that patients do not have a physical impairment, as reflected by a normal quality of life of CDH patients. Pediatr Pulmonol. 2007; 42:325\u2013331. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20579","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T03:20:09Z","timestamp":1173928809000},"page":"325-331","source":"Crossref","is-referenced-by-count":41,"title":["Pulmonary function and exercise testing in adult survivors of congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"42","author":[{"given":"Marieke G.","family":"Peetsold","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Vonk\u2010Noordegraaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo H.","family":"Heij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinoud 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