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Frequent wheezing in the first 3 years of life with risk factors for asthma (e.g., eczema, maternal asthma) predicts symptoms in older age, while infrequent viral\u2010associated wheezing without risk factors for asthma has a benign prognosis. This systematic review summarizes evidence on the use of anti\u2010inflammatory medications in preschool children with wheezing. Literature search was performed using Medline and the Cochrane Library. Retrieved articles were critically appraised. Episodic use of high\u2010dose inhaled corticosteroids (&gt;1,600 mcg\/day of beclomethasone) may ameliorate severity of intermittent viral\u2010associated wheezing. Maintenance inhaled corticosteroids can control symptoms in children with frequent wheezing associated with risk factors for asthma. Inhaled corticosteroids do not alter the natural history of wheezing even when started early in life and could have a negative impact on linear growth rate. Short courses of oral corticosteroids have been proposed as an effective measure to control exacerbations of symptoms although there is little evidence supporting their use. Some studies support the administration of non\u2010steroidal anti\u2010inflammatory medications (leukotriene pathway modifiers, cromones, methylxanthines) for mild frequent wheezing. Maintenance inhaled corticosteroids is the most effective measure for controlling frequent wheezing in preschool children, especially when accompanied by risk factors for asthma. This treatment does not affect the natural history of wheezing, although deceleration of linear growth rate is the most commonly recognized systemic adverse effect. Pediatr Pulmonol. 2007; 42:407\u2013420. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20591","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T03:21:36Z","timestamp":1173928896000},"page":"407-420","source":"Crossref","is-referenced-by-count":44,"title":["Anti\u2010inflammatory pharmacotherapy for wheezing in preschool children"],"prefix":"10.1002","volume":"42","author":[{"given":"Athanasios G.","family":"Kaditis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenna","family":"Winnie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Syrogiannopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10243"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200504-525OC"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054692"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051378"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200407-894OC"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69285-4"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.3.e48"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470693926"},{"key":"e_1_2_1_10_2","volume-title":"Evidence\u2010based medicine. 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