{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:26:17Z","timestamp":1791033977657,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T00:00:00Z","timestamp":1177632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We studied the changes in the patterns of lung function and somatic growth over time in children and adolescents (10.6\u2009\u00b1\u20093.5 years at first test) with hemoglobin SS (Hb\u2010SS) sickle cell disease (SCD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lung function and somatic growth were measured twice with an interval of 42.3\u2009\u00b1\u200923.3 months in 45 children (25 females and 20 males) with Hb\u2010SS SCD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The lung volumes slightly decreased but remained borderline normal in both tests. All spirometric indices were within the normal range but significantly decreased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) at the time of the second test indicating development of lower airway obstruction (forced expiratory volume in the first second (FEV<jats:sub>1<\/jats:sub>): 87\u2009\u00b1\u200921 vs. 80\u2009\u00b1\u200915; FEV<jats:sub>1<\/jats:sub>\/forced vital capacity (FVC): 89\u2009\u00b1\u20097 vs. 85\u2009\u00b1\u20096; FEF<jats:sub>25\u201375<\/jats:sub>: 89\u2009\u00b1\u200932 vs. 76\u2009\u00b1\u200924). \u201cNormal\u201d pattern of lung function was initially found in 56% of the patients, but in only 29% in the second test. In contrast, those with \u201cobstructive\u201d pattern increased from 22 to 44%, and those with \u201crestrictive\u201d pattern from 22 to 27%. There was no association between history of asthma and pattern of lung function. \u201cNormal\u201d Body Mass Index (BMI) was found in 64% of the patients, whereas 13% had \u201cHigh\u201d BMI and 22% \u201cLow\u201d BMI. The two latter patterns were associated with abnormal lung function but only patients with normal BMI showed actual decline overtime.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SCD is characterized by a predominantly obstructive pattern of lung function that increases in prevalence over time. There was no apparent causal relationship between the pattern of somatic growth and the pattern of lung function. Pediatr Pulmonol. 2007; 42:483\u2013488. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.20601","type":"journal-article","created":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T20:51:15Z","timestamp":1177707075000},"page":"483-488","source":"Crossref","is-referenced-by-count":59,"title":["Longitudinal changes in lung function and somatic growth in children with sickle cell disease"],"prefix":"10.1002","volume":"42","author":[{"given":"Anastassios C.","family":"Koumbourlis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,27]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198801000-00005"},{"issue":"5","key":"e_1_2_1_3_2","first-page":"574","article-title":"Pulmonary function studies in sickle cell disease","volume":"28","author":"Femi\u2010Pearce D","year":"1970","journal-title":"J Appl Phys"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.26.3.309"},{"issue":"5","key":"e_1_2_1_5_2","first-page":"509","article-title":"Lung function in sickle cell hemoglobinopathy patients compared with healthy subjects","volume":"80","author":"Young RC","year":"1988","journal-title":"J Nat Med Assoc"},{"issue":"4","key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1542\/peds.71.4.610","article-title":"Body shape in young children with homozygous sickle cell disease","volume":"71","author":"Stevens MC","year":"1983","journal-title":"Pediatrics"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198407053110102"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80351-0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.82.3.204"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-4409(01)00360-5"},{"issue":"1","key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1542\/peds.78.1.124","article-title":"Prepubertal growth and skeletal maturation in children with sickle cell disease","volume":"78","author":"Stevens MC","year":"1986","journal-title":"Pediatrics"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83418-3"},{"key":"e_1_2_1_13_2","first-page":"67","article-title":"Pulmonary function abnormalities in children with sickle cell disease","volume":"59","author":"Sylvester KP","year":"2004","journal-title":"Thorax"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199710)24:4<277::AID-PPUL6>3.0.CO;2-H"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12051124"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.111824"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9712108"},{"key":"e_1_2_1_18_2","first-page":"879","article-title":"Standards of pulmonary function in children","volume":"99","author":"Weng TR","year":"1969","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030492"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035205"},{"key":"e_1_2_1_21_2","unstructured":"KuczmarskiRJ OgdenCL Grummer\u2010StrawnLM et al.CDC Growth charts United States. 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