{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T20:04:50Z","timestamp":1775851490191,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,8,28]],"date-time":"2007-08-28T00:00:00Z","timestamp":1188259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Several options are currently available in neonatal mechanical ventilation: complete breathing synchronization (patient triggered ventilation, synchronized intermittent positive pressure ventilation\u2014SIPPV); positive pressure flow\u2010cycled ventilation (pressure support ventilation, PSV); and volume targeted positive pressure ventilation (volume guarantee, VG). The software algorithm for the guarantee volume attempts to deliver a tidal volume (Vt) as close as possible to what has been selected by the clinician as the target volume. Main objectives of the present study were to compare patient\u2013ventilator interactions and Vt variability in premature infants recovering from respiratory distress syndrome (RDS) who were weaned by various ventilator modes (SIMV\/PSV\u2009+\u2009VG\/SIPPV\u2009+\u2009VG and SIMV\u2009+\u2009VG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a short\u2010term crossover trial in which each infant served as his\/her own control. Ten premature infants born before the 32nd week of gestation in the recovery phase of RDS were enrolled in the study. All recruited infants started ventilation with SIPPV and in the weaning phase were switched to synchronized intermittent mandatory ventilation (SIMV). Baseline data were collected during an initial 20\u2010min period of monitoring with the infant receiving SIMV alone, then they were switched to SIPPV\u2009+\u2009VG for a 20\u2010min period and then switched back to SIMV for 15 min. Next, they were switched to PSV\u2009+\u2009VG for the study period and switched back to SIMV for a further 15 min. Finally, they were switched to SIMV\u2009+\u2009VG and, at the end of monitoring, they were again switched back to SIMV alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Each mode combined with VG discharged comparable Vts, which were very close to the target volume. Among the VG\u2010combined modes, mean variability of Vt from preset Vt was significantly different. Variability from the target value was significantly lower in SIPPV and PSV modes than in SIMV (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001 and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.04 respectively). SIPPV\u2009+\u2009VG showed greater stability of Vt, fewer large breaths, lower respiratory rate, and allowed for lower peak inspiratory pressure than what was delivered by the ventilator during other modes. No significant changes in blood gases were observed after each of the study periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>With regards to the weaning phase, among combined modes, both of the ones in which every breath is supported (SIPPV\/PSV) are likely to be the most effective in the delivery of stable Vt using a low working pressure, thus, at least in the short term, likely more gentle for the neonatal lung. In summary, we can suggest that the VG option, when combined with traditional, patient triggered ventilation, adheres very closely to the proposed theoretical algorithm, achieving highly effective ventilation. Pediatr Pulmonol. 2007; 42:864\u2013870. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.20667","type":"journal-article","created":{"date-parts":[[2007,8,28]],"date-time":"2007-08-28T23:46:32Z","timestamp":1188344792000},"page":"864-870","source":"Crossref","is-referenced-by-count":31,"title":["Volume targeted ventilation (volume guarantee) in the weaning phase of premature newborn infants"],"prefix":"10.1002","volume":"42","author":[{"given":"F.","family":"Scopesi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.G.","family":"Calevo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Rolfe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Arioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Traggiai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.M.","family":"Risso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Serra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/siny.2002.0136"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.87.1.F3"},{"key":"e_1_2_1_4_2","first-page":"165","volume-title":"Assisted ventilation of the neonate","author":"Spitzer AR","year":"2003"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.3.8630564"},{"key":"e_1_2_1_6_2","first-page":"204","volume-title":"Assisted ventilation of the neonate","author":"Donn SM","year":"2003"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000161071.47031.61"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20350"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199412000-00009"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10273"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.72.3.F188"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70044-7"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199510000-00020"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.3.529"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.6.1323"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1091"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20063"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211313"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211370"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20384"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.112102"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.1.9604014"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000139619.27651.86"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/137.5.1159"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2006.12.011"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10458"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20667","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.20667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T07:28:25Z","timestamp":1696663705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.20667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,28]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1002\/ppul.20667"],"URL":"https:\/\/doi.org\/10.1002\/ppul.20667","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,28]]}}}