{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:49:33Z","timestamp":1760622573130},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,8,24]],"date-time":"2007-08-24T00:00:00Z","timestamp":1187913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary cilliary dyskinesia (PCD) is characterized by decreased levels of fractional exhaled nitric oxide (FeNO), thought to reflect low activity of airway inducible nitric oxide synthase (iNOS) levels. Alveolar NO (C<jats:sub>alv<\/jats:sub>) concentration and bronchial NO (J<jats:sub>NO<\/jats:sub>) flux can be calculated from FeNO measured at multiple exhalation flow rates. We hypothesised that whereas bronchial NO would be reduced in PCD due to reduced iNOS function, alveolar NO would reflect endothelial NOS (eNOS) function and be normal. We recorded the medical history; measured FeNO at multiple flow rates (50, 100, 200, 260 ml\/sec); and performed spirometry in 24 children (aged 8\u201316 years). FeNO<jats:sub>50<\/jats:sub> of the PCD children was significantly lower than normal mean (\u00b1SD) 8.1\u2009\u00b1\u20091.3 ppb versus 12.5\u2009\u00b1\u20091.6 ppb, <jats:italic>P<\/jats:italic>\u2009=\u20090.033. The mean\u2009\u00b1\u2009SD values of PCD (n\u2009=\u200924) and normal (n\u2009=\u200920) subjects were respectively: J<jats:sub>NO<\/jats:sub>: 383.5\u2009\u00b1\u2009307.9 versus 650.1\u2009\u00b1\u2009489 pl\/s, <jats:italic>P<\/jats:italic>\u2009=\u20090.033, C<jats:sub>alv<\/jats:sub>: 1.60\u2009\u00b1\u20090.78 versus 1.60\u2009\u00b1\u20090.75 ppb, <jats:italic>P<\/jats:italic>\u2009=\u2009NS. We show that C<jats:sub>alv<\/jats:sub> is normal in PCD, demonstrating that there is no generalized disorder of NO handling in this condition. This differs from a previous report. Furthermore, we speculate that these data may provide supportive evidence that variable flow NO measurements can assess the relative activity of iNOS and eNOS. Pediatr Pulmonol. 2007; 42:876\u2013880. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20670","type":"journal-article","created":{"date-parts":[[2007,8,25]],"date-time":"2007-08-25T01:21:11Z","timestamp":1188004871000},"page":"876-880","source":"Crossref","is-referenced-by-count":23,"title":["Nitric oxide production in PCD: Possible evidence for differential nitric oxide synthase function"],"prefix":"10.1002","volume":"42","author":[{"given":"Emmanouil","family":"Paraskakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadwa","family":"Zihlif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Bush, MB, BS (Hons), MA, MD, FRCP, FRCPCH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12040982"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.7.586"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(00)89123-4"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1187"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.2.653"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.1.477"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00293102"},{"key":"e_1_2_1_9_2","first-page":"1107","article-title":"Standardization of spirometry. 1994 update","volume":"152","author":"American Thoracic Society","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.13f28.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200506-962OC"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2010171"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.3.1012"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00202002"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.00000201"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20202"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1.118"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.12.005"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20329"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.2.633"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00575.2003"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.4.9903111"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117585"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.4A6453.2005"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.12.6.7539274"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200102000-00011"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853899509002592"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10102376"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200303-365OC"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20670","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20670","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.20670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T07:27:57Z","timestamp":1696663677000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.20670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,24]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1002\/ppul.20670"],"URL":"https:\/\/doi.org\/10.1002\/ppul.20670","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,24]]}}}