{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T22:31:26Z","timestamp":1773354686904,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,8,28]],"date-time":"2007-08-28T00:00:00Z","timestamp":1188259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Status asthmaticus is one of the most common causes of admission to a pediatric intensive care unit (PICU). There is little published data, however, examining the complications associated with the treatment of status asthmaticus in children in the PICU. Our hypothesis was that children experiencing a complication would have an increased duration of hospitalization for status asthmaticus. We performed a retrospective review of the complication profile and hospital course of all children admitted to a PICU with status asthmaticus over a 9 years period. Twenty\u2010two (8%) of the 293 children admitted to the ICU with status asthmaticus experienced one or more complications during their treatment. The most common complications were aspiration pneumonia, ventilator\u2010associated pneumonia, pneumomediastinum, pneumothorax, and rhabdomyolysis. Intubated children were significantly more likely than non\u2010intubated children to experience a complication (RR 15.3; 95% CI 6.7\u201335). Fifteen (42%) of the 36 intubated children experienced a complication. Intubated children experiencing a complication had significantly longer duration of mechanical ventilation (163\u2009\u00b1\u2009169 hr vs. 66\u2009\u00b1\u200965 hr, <jats:italic>P<\/jats:italic>\u2009=\u20090.03), ICU length of stay (237\u2009\u00b1\u2009180 hr vs. 124\u2009\u00b1\u200986 hr, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and hospital charges ($117,184\u2009\u00b1\u2009111,191 vs. $38,788\u2009\u00b1\u200927,784; <jats:italic>P<\/jats:italic>\u2009=\u20090.001) than intubated children not experiencing a complication. In this review, complications were associated with increased morbidity and duration of hospitalization in children with status asthmaticus, particularly in those intubated as part of their therapy. This suggests that intubation and mechanical ventilation itself may increase the risk of developing a complication in this population. Pediatr Pulmonol. 2007; 42:914\u2013919. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20682","type":"journal-article","created":{"date-parts":[[2007,8,28]],"date-time":"2007-08-28T23:17:32Z","timestamp":1188343052000},"page":"914-919","source":"Crossref","is-referenced-by-count":33,"title":["The increased cost of complications in children with status asthmaticus"],"prefix":"10.1002","volume":"42","author":[{"given":"Christopher L.","family":"Carroll","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron R.","family":"Zucker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,28]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"To Err is human: Building a safer health system","author":"Kohn KT","year":"1999"},{"key":"e_1_2_1_3_2","volume-title":"Crossing the Quality Chasm: a New Health System for the 21st Century","author":"Institute of Medicine","year":"2001"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.6.1913"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/thorax.58.1.81","article-title":"The pulmonary physician in critical care: acute severe asthma in the intensive care unit","volume":"58","author":"Phipps P","year":"2003","journal-title":"Thorax"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc1451"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.05.008"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000257115.02573.FC"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/136.4.872"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.3.607"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199311000-00023"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.2.517"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8627(05)70240-6"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950110208"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.1990.tb02449.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80691-2"},{"key":"e_1_2_1_17_2","unstructured":"National Asthma Education and Prevention Program.Expert panel report 2: Guidelines for the diagnosis and management of asthma Bethesda Maryland: National Heart Lung and Blood Institute; NIH Publication No. 97\u201040511997."},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60987-8"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421801"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000112374.68746.E8"},{"key":"e_1_2_1_21_2","first-page":"385","article-title":"Mechanical controlled hypoventilation in status asthmaticus","volume":"129","author":"Darioli R","year":"1984","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000201336.16278.D4"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20682","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.20682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T07:28:37Z","timestamp":1696663717000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.20682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,28]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1002\/ppul.20682"],"URL":"https:\/\/doi.org\/10.1002\/ppul.20682","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,28]]}}}