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Studies on the efficacy of these have been mainly conducted in adults, and in patients with cystic fibrosis (CF). The exact role of mucoactive agents in children with non\u2010CF lung disease is not well established. We present an overview of the current literature reporting clinical outcome measures of treatment with NAC, rhDNase, and hypertonic saline in children. 2007;42:989\u20131001. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20693","type":"journal-article","created":{"date-parts":[[2007,9,27]],"date-time":"2007-09-27T16:50:09Z","timestamp":1190911809000},"page":"989-1001","source":"Crossref","is-referenced-by-count":33,"title":["Pharmacotherapy of impaired mucociliary clearance in non\u2010CF pediatric lung disease. 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