{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:52Z","timestamp":1772118832308,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T00:00:00Z","timestamp":1192665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Measurement of the response of acute bronchiolitis (AB) to bronchodilators relies on clinical signs and pulse oximetry. We hypothesized that Doppler ultrasonographic indices of hepatic venous flow may prove to be an objective tool in the assessment of the effect of inhaled salbutamol in infants hospitalized for AB. Previously healthy infants hospitalized for their first episode of AB were prospectively studied. Composite clinical score (CCS, retractions\n                    <jats:italic>plus<\/jats:italic>\n                    wheezing\/crackles) and hemoglobin oxygen saturation (SaO\n                    <jats:sub>2<\/jats:sub>\n                    ) were measured before, and 15\u2010min post\u2010salbutamol nebulization (0.15 mg\/kg, minimum 1.5 mg). Peak velocities at the middle hepatic vein (PV\u2010HV) and right renal vein (PV\u2010RV), as well as peripheral\u2010to\u2010middle hepatic vein transit time (TT) of an ultrasound contrast agent were also measured by Doppler ultrasonography pre\u2010 and post\u2010nebulization. Nineteen infants were studied. Mean CCS decreased by 0.37 (95% confidence interval [CI]: 0.08\u20130.66,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.015) and mean SaO\n                    <jats:sub>2<\/jats:sub>\n                    increased by 0.68% (95%CI: 0.17\u20131.19,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.01) post\u2010bronchodilator treatment. Mean TT increased by 9.54 sec (95%CI: 5.95\u201313.13,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0001) and PV\u2010HV increased by 16.49 cm\/sec (95%CI: 9.07\u201323.91,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.0002); PV\u2010RV did not change. TT (r\u2009=\u20090.51,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.009), but not PV\u2010HV, correlated negatively with CCS. There was a strong positive correlation between pre\u2010 and post\u2010salbutamol TT values (r\u2009=\u20090.92,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.0001). The most likely explanation for these findings is post\u2010salbutamol abolishment of shunting at the pulmonary capillary bed. We conclude that the peripheral\u2010to\u2010middle hepatic vein prolongation of TT measured by Doppler ultrasonography after salbutamol administration in infants with AB can be used as a bedside tool in the objective assessment of clinical response to medication in these patients. Pediatr Pulmonol. 2007; 42:1159\u20131165. \u00a9 2007 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ppul.20711","type":"journal-article","created":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T17:46:53Z","timestamp":1192729613000},"page":"1159-1165","source":"Crossref","is-referenced-by-count":0,"title":["Use of Doppler ultrasonography in the assessment of bronchodilator response in acute bronchiolitis"],"prefix":"10.1002","volume":"42","author":[{"given":"Christina","family":"Kalogeropoulou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael 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