{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:26:04Z","timestamp":1782231964227,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,12,18]],"date-time":"2007-12-18T00:00:00Z","timestamp":1197936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare immediate extubation versus delayed extubation after 36 hr in extremely low\u2010birth weight infants receiving gentle mechanical ventilation and perinatal lung protective interventions. Our hypothesis was that a delayed extubation in this setting would decrease the rate of reintubation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design\/Methodology<\/jats:title><jats:p>A prospective, unmasked, randomized, controlled trial to compare immediate extubation and delayed extubation after 36 hr. Optimized ventilation in both groups included continuous tracheal gas insufflation (CTGI), prophylactic surfactant administration, low oxygen saturation target and moderate permissive hypercapnia. Successful extubation for at least 7 days was the primary criterion and ventilatory support requirements until 36 weeks gestational age the main secondary criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient selection<\/jats:title><jats:p>Eighty\u2010six infants under 28 weeks gestational age in a single neonatal intensive tertiary care unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Delayed extubation (1.9\u2009\u00b1\u20090.8 days vs. 0.5\u2009\u00b1\u20090.7 days) did not improve the rate of successful extubation but had no long\u2010term adverse effects. CTGI and the lung protective strategy we describe resulted in a very gentle ventilation. The rate of survival without bronchopulmonary dysplasia (BPD, defined as any respiratory support at 36 weeks gestational age) was similar in the two groups and remarkably high for the global population (78%) and for the subgroup of infants &lt;1,000 g at birth (75%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adding 36 hr of optimized mechanical ventilation before first extubation does not improve the rate of successful extubation but has no adverse effects. Pediatr Pulmonol. 2008; 43:117\u2013124. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.20726","type":"journal-article","created":{"date-parts":[[2007,12,18]],"date-time":"2007-12-18T20:46:47Z","timestamp":1198010807000},"page":"117-124","source":"Crossref","is-referenced-by-count":31,"title":["A randomized trial of delayed extubation for the reduction of reintubation in extremely preterm infants"],"prefix":"10.1002","volume":"43","author":[{"given":"Claude","family":"Danan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Durrmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Brochard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Decobert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Benani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Dassieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,26]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10032"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199912000-00007"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200104000-00006"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.6.e560"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.2.e24"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.4.1471"},{"key":"e_1_2_1_8_2","first-page":"CD003063","article-title":"Early surfactant administration with brief ventilation vs selective surfactant and continued mechanical ventilation for preterm infants with or at risk for respiratory distress syndrome","volume":"3","author":"Stevens TP","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.5.1082"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.5.1031"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00891.2006"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00211.2003"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)31081-7"},{"key":"e_1_2_1_14_2","first-page":"CD000144","article-title":"Natural surfactant extract versus synthetic surfactant for neonatal respiratory distress syndrome","volume":"2","author":"Soll RF","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000510"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000092870"},{"key":"e_1_2_1_17_2","first-page":"CD000174","article-title":"Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants","volume":"3","author":"Fowlie PW","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050719"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20094"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.3.9910063"},{"key":"e_1_2_1_21_2","first-page":"CD001145","article-title":"Delayed (>3 weeks) postnatal corticosteroids for chronic lung disease in preterm infants","volume":"1","author":"Halliday HL","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_1_22_2","first-page":"CD001144","article-title":"Moderately early (7\u201314 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants","volume":"1","author":"Halliday HL","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2006.05.006"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.092478"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000020601.28483.A1"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(90)90136-7"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20726","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.20726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T16:50:43Z","timestamp":1699980643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.20726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,26]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1002\/ppul.20726"],"URL":"https:\/\/doi.org\/10.1002\/ppul.20726","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,26]]}}}