{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:10:27Z","timestamp":1787242227600,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T00:00:00Z","timestamp":1196035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH HD","award":["29067"],"award-info":[{"award-number":["29067"]}]},{"name":"NIH HD","award":["29071"],"award-info":[{"award-number":["29071"]}]},{"name":"NIH HD","award":["28971"],"award-info":[{"award-number":["28971"]}]},{"name":"NIH HD","award":["29073"],"award-info":[{"award-number":["29073"]}]},{"name":"NIH HD","award":["29060"],"award-info":[{"award-number":["29060"]}]},{"name":"NIH HD","award":["20056"],"award-info":[{"award-number":["20056"]}]},{"name":"NIH HD","award":["34625"],"award-info":[{"award-number":["34625"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In 1,079 infants monitored for &gt;700,000 hr at home for apnea or bradycardia, we found an association between infants having multiple events exceeding conventional or a priori defined more extreme thresholds and less favorable developmental outcome at 1 year of age than infants with few or no events. If it is necessary to prevent such events to minimize risk for developmental morbidity, there is reason to determine whether there are disturbances in advance of the apnea or bradycardia that herald their onset. In the 85 infants with at least 1 extreme event and 1 conventional event, we hypothesized that apnea and bradycardia do not occur de novo but rather are preceded by cardiorespiratory and hemoglobin O\n                    <jats:sub>2<\/jats:sub>\n                    saturation changes. We compared recorded time intervals preceding these events, and we analyzed three preceding time intervals for each conventional and extreme event, and each non\u2010event recording: Time\u20102 hr: up to 2 hr before; Time\u20101 hr: up to 1 hr before; and Time\u201075 sec: the 75 sec immediately preceding each event. O\n                    <jats:sub>2<\/jats:sub>\n                    saturation progressively decreased preceding both conventional and extreme events, and progressive increases occurred in heart and breathing rate variability. Duration of respiratory pauses and of periodic breathing progressively increased preceding conventional events, respiratory rate variability increased immediately preceding conventional events and at 1 hr preceding extreme events, and O\n                    <jats:sub>2<\/jats:sub>\n                    saturation decreased immediately preceding both conventional and extreme events. Thus, conventional and extreme events do not occur de novo but rather are preceded by autonomic instability of the cardiorespiratory system. Pediatr Pulmonol. 2008; 43:87\u201398. \u00a9 2007 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ppul.20745","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T18:26:43Z","timestamp":1196101603000},"page":"87-98","source":"Crossref","is-referenced-by-count":21,"title":["Precursors of cardiorespiratory events in infants detected by home memory monitor"],"prefix":"10.1002","volume":"43","author":[{"given":"Carl E.","family":"Hunt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Corwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Lister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra E.","family":"Weese\u2010Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally L. Davidson","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry R.","family":"Tinsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Neuman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Willinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rangasamy","family":"Ramanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Rybin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and the Collaborative Home Infant Monitoring Evaluation (CHIME) Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.17.2199"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.05.045"},{"key":"e_1_2_1_4_2","volume-title":"2003 Applied Longitudinal Data Analysis: Modeling Change and Event Occurrence","author":"Singer JD","year":"1994"},{"key":"e_1_2_1_5_2","unstructured":"SAS 8.2 SAS Institute Cary NC."},{"key":"e_1_2_1_6_2","first-page":"471","article-title":"Comparison of apnea identified by respiratory inductance plethysmography with that detected by end\u2010tidal CO2 or thermistor","volume":"162","author":"Weese\u2010Mayer DE","year":"2000","journal-title":"AJRCCM"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199811000-00010"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/22\/2\/301"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70056-9"},{"key":"e_1_2_1_10_2","first-page":"346","article-title":"Sudden infant death syndrome and other causes of infant mortality: Diagnosis, mechanisms, and risk for recurrence in siblings","volume":"164","author":"Hunt CE","year":"2001","journal-title":"AJRCCM"},{"key":"e_1_2_1_11_2","first-page":"535","volume-title":"Neonatology, pathophysiology and management of the newborn","author":"Thompson MW","year":"2005"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1006201"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199907000-00006"},{"key":"e_1_2_1_14_2","first-page":"319","article-title":"Fetal heart rates in siblings of infants with sudden infant death syndrome","volume":"58","author":"Hoppenbrouwers T","year":"1981","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1542\/peds.93.1.44","article-title":"Cardiorespiratory recordings from infants dying suddenly and unexpectedly at home","volume":"93","author":"Meny RG","year":"1994","journal-title":"Pediatrics"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199903000-00010"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1109\/CIC.2002.1166840","article-title":"Comparison of heart rate variability measurements in infants","volume":"29","author":"Xu X","year":"2002","journal-title":"Comput Cardiol"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20745","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20745","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.20745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T07:24:08Z","timestamp":1699946648000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.20745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,28]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1002\/ppul.20745"],"URL":"https:\/\/doi.org\/10.1002\/ppul.20745","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,28]]}}}