{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T10:29:42Z","timestamp":1777112982072,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,1,23]],"date-time":"2008-01-23T00:00:00Z","timestamp":1201046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the short and long\u2010term clinical effects and the treatment\u2010feasibility of inhaled\u2010furosemide (IF) as compared with placebo via hood in hospitalized infants with viral\u2010bronchiolitis (VB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study\u2010Design<\/jats:title><jats:p>A randomized, double\u2010blind, placebo\u2010controlled pilot\u2010study was performed in previously healthy infants (0\u201312 months). Enrolled infants were randomized to receive either IF (2 mg\/kg), or placebo nebulized by hood three times daily throughout the hospitalization. Clinical assessment (respiratory distress assessment instrument [RDAI]) was performed before, 30 and 60 min after the 1st daily inhalation. The short\u2010term effects were evaluated by the RDAI, respiratory assessment change score (RACS) and oxygen requirement and the long\u2010term effects by time to be weaned off oxygen, time to full enteral feeding, length of stay, and \u201cready to discharge\u201d time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups (16 infants each) had comparable characteristics at study entry. Mean (\u00b1SD) age was 72\u2009\u00b1\u200943 days, and 29\/32 infants were RSV positive. Oxygen requirement (FiO<jats:sub>2<\/jats:sub>) decreased significantly at 30 min post\u2010inhalation (30\u2009\u00b1\u20099.2% to 26\u2009\u00b1\u20097.1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) only in the IF group. RACSs and long\u2010term effects of both groups were comparable. Analysis of IF particles generated by the hood\u2010nebulizer demonstrated that 36% and 49% of the particles were &lt;3 and 5 \u00b5m, respectively. No side effects were observed during IF treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on our pilot study, IF has no significant clinical effects in hospitalized infants with VB. IF via hood seems to be feasible and safe. Pediatr Pulmonol. 2008; 43:261\u2013267. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.20765","type":"journal-article","created":{"date-parts":[[2008,1,23]],"date-time":"2008-01-23T19:48:25Z","timestamp":1201117705000},"page":"261-267","source":"Crossref","is-referenced-by-count":15,"title":["Inhaled furosemide in hospitalized infants with viral bronchiolitis: A randomized, double\u2010blind, placebo\u2010controlled pilot 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