{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:48:26Z","timestamp":1767851306713,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,2,27]],"date-time":"2008-02-27T00:00:00Z","timestamp":1204070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare airway function in early adulthood in subjects with wheezing in infancy with age\u2010matched controls and to analyze what accounts for a possible difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Asthma development has been prospectively studied in 101 children hospitalized due to wheezing before the age of two. The cohort was re\u2010investigated at age 17\u201320 years and tested with spirometry and for bronchial hyper\u2010responsiveness and allergic sensitization. An age\u2010matched population (n\u2009=\u2009294) was used for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort had a significantly lower FEV<jats:sub>1<\/jats:sub>\/FVC ratio and MEF<jats:sub>50<\/jats:sub>, both pre\u2010 and post\u2010bronchodilation, compared with the controls, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01. The reduction in airway function was most evident in current asthmatic female subjects, but a reduced pre\u2010bronchodilation FEV<jats:sub>1<\/jats:sub>\/FVC ratio was also seen in symptom\u2010free cohort subjects, <jats:italic>P<\/jats:italic>\u2009=\u20090.03. In the multivariate analysis, female gender was the most prominent independent risk factor for reduced airway function in early adulthood, pre\u2010bronchodilation OR 4.0 (1.4\u201311.3) and post\u2010bronchodilation OR 8.8 (1.8\u201342.0). In addition, a history of early wheezing, that is, belonging to the cohort, was an independent risk factor for reduced airway function pre\u2010bronchodilation, OR 3.3 (1.3\u20138.7). Furthermore, there was an association between current bronchial hyper\u2010responsiveness and an increased risk of reduced airway function post\u2010bronchodilation, OR 7.3 (2.0\u201326.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced airway function in early adulthood was found in subjects with wheezing early in life, compared with age\u2010matched controls. The reduction was most prominent in females with current asthma. 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