{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:43:20Z","timestamp":1767858200785,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,4,24]],"date-time":"2008-04-24T00:00:00Z","timestamp":1208995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Mycoplasma (M.) pneumoniae<\/jats:italic> has been associated with exacerbation of symptoms in asthmatic school children and adults; and an etiological role in asthma has been suggested. The purpose of this study was to investigate whether infection with <jats:italic>M. pneumoniae<\/jats:italic> in early childhood has a long\u2010term influence on lung function and bronchial responsiveness. In a retrospective, clinical cohort\u2010study children younger than 5 years\u2010of\u2010age when PCR\u2010tested for <jats:italic>M. pneumoniae<\/jats:italic> were enrolled. Sixty\u2010five children with clinical symptoms suggesting infection with <jats:italic>M. pneumoniae<\/jats:italic> during an epidemic season completed a clinical follow\u2010up examination including lung function testing (28 PCR\u2010positive and 37 PCR\u2010negative). In addition to the PCR\u2010test for <jats:italic>M. pneumoniae<\/jats:italic> all respiratory tract specimens were additionally tested for other atypical bacteria and for viruses by PCR. Lung function was measured as specific airway resistance by whole\u2010body plethysmography and bronchial hyperresponsiveness was assessed by cold, dry air hyperventilation. Neither baseline lung function nor bronchial response to cold dry air hyperventilation differed between <jats:italic>M. pneumoniae<\/jats:italic>\u2010positive and \u2010negative children: mean baseline lung function were 1.17 versus 1.21 (kPa\u2009sec), <jats:italic>P<\/jats:italic>\u2009=\u20090.45; and mean change in specific resistance was 13% versus 9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.42. In conclusion, <jats:italic>M. pneumoniae<\/jats:italic> infection in early childhood was not associated with long\u2010term effects on lung function and bronchial hyperresponsiveness 2 years after infection. Pediatr Pulmonol. 2008; 43:567\u2013575. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20813","type":"journal-article","created":{"date-parts":[[2008,4,24]],"date-time":"2008-04-24T22:47:41Z","timestamp":1209077261000},"page":"567-575","source":"Crossref","is-referenced-by-count":12,"title":["Lung function and bronchial responsiveness after <i>Mycoplasma pneumoniae<\/i> infection in early childhood"],"prefix":"10.1002","volume":"43","author":[{"given":"Birgitte B.","family":"Kjaer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen S.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim G.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Fomsgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blenda","family":"B\u00f6ttiger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birthe","family":"Dohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Bisgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,24]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"2259","volume-title":"Textbook of pediatric infectious diseases","author":"Cherry JD","year":"1998"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10346"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(01)00147-5"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(88)97604-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.2.372"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200008000-00007"},{"key":"e_1_2_1_8_2","first-page":"43","article-title":"The association of viral and mycoplasma infections with recurrence of wheezing in the asthmatic child","volume":"28","author":"Berkovich S","year":"1970","journal-title":"Ann Allergy"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.4.2105129a"},{"key":"e_1_2_1_10_2","first-page":"263","article-title":"Mycoplasma pneumoniae is a frequent cause of exacerbation of bronchial asthma in adults","volume":"57","author":"Seggev JS","year":"1986","journal-title":"Ann Allergy"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.5.8173777"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200412-1743PP"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08122067"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.6.9905098"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.1.261-266.2003"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1989.tb00516.x"},{"key":"e_1_2_1_17_2","unstructured":"JensenJS.Direct detection ofMycoplasma pneumoniaein clinical samples. 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