{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T01:08:02Z","timestamp":1774487282165,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,5,23]],"date-time":"2008-05-23T00:00:00Z","timestamp":1211500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cystic fibrosis (CF) is the most prevalant inheritable chronic disease in caucasian children. The clinical syndrome of kwashiorkor is well\u2010recognized complication of CF. The edema of the face can be seen in kwashiorkor. As doll\u2010like face is very rare and underestimated clinical presentation of CF patients complicated with hypoproteinemia we evaluated demographic features and laboratory characteristics of 5 patients diagnosed as CF with doll\u2010like face. Methods: Between June 2005 and January 2008, 115 children were diagnosed as having CF enrolled in our center. Five infants were diagnosed as CF with doll\u2010like face before the age of 6 months participitated in study. Results: The incidence of doll\u2010like face younger than the 6 months of age were 9.4% in our center. 48 infants diagnosed as CF without doll\u2010like face before the age of 6 months participitated in the study as controls (group2). Physical examination revealed doll\u2010like face and pitting edema of lower extremities in group 1. Their weight and length were under the third centile. Laboratory findings of group 1 include: mean hemoglobin 7.6g\/dl; mean total protein 4.4 g\/dl; albumin 2.3 g\/dl. When compared control group in order to; 11.4 g\/dl (range 7.6\u201317.9); 6.2 g\/dl (range 4.0\u20138.8); 4.7 g\/dl (range 2.1\u20135.8). mean hemoglobin, total protein and albumin values were lower in group 1. Conclusion: In a subgroup of patients, doll\u2010like face may be the presenting manifestation of CF. Especially in developing countries clinicians should be aware of in patients with malnutrition and doll\u2010like face and CF should be considered in differential diagnosis. Pediatr Pulmonol. 2008; 43:634\u2013637. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20819","type":"journal-article","created":{"date-parts":[[2008,5,23]],"date-time":"2008-05-23T18:52:43Z","timestamp":1211568763000},"page":"634-637","source":"Crossref","is-referenced-by-count":4,"title":["Doll\u2010like face: Is it an underestimated clinical presentation of cystic fibrosis?"],"prefix":"10.1002","volume":"43","author":[{"given":"Mehmet","family":"Kose","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevgi","family":"Pekcan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nural","family":"Kiper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse Tana","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazan","family":"Cobanoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Yalcin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz","family":"Dogru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"Ozcelik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,24]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"209","volume-title":"Cystic fibrosis","author":"Godding I","year":"2007"},{"key":"e_1_2_1_3_2","first-page":"165","article-title":"Newborn screening for cystic fibrosis with the chloride electrode and neutron activation analysis","volume":"28","author":"Gurson CT","year":"1973","journal-title":"Helv Paediatr Acta"},{"key":"e_1_2_1_4_2","first-page":"99","volume-title":"Cystic fibrosis","author":"Wallis C","year":"2007"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198605000-00010"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.8.724"},{"key":"e_1_2_1_7_2","first-page":"57","article-title":"Hypoproteinemia and cystic fibrosis","volume":"104","author":"Nebert DW","year":"1966","journal-title":"Calif Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198201030-00013"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80194-3"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.228.5.585"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19870008"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19790008"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90053-1"},{"key":"e_1_2_1_14_2","first-page":"496","article-title":"Effects of kwashiorkor malnutrition on measured capillary filtration rate in the forearm","volume":"262","author":"Richardson D","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80320-8"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1986.tb10264.x"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20819","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.20819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T23:29:07Z","timestamp":1697153347000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.20819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1002\/ppul.20819"],"URL":"https:\/\/doi.org\/10.1002\/ppul.20819","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}