{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T14:40:09Z","timestamp":1788014409156,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,4,24]],"date-time":"2008-04-24T00:00:00Z","timestamp":1208995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Respiratory symptoms are common in infancy. Most illnesses occurring among children are dealt with by parents and do not require medical attention. Nevertheless, few studies have prospectively and on a community\u2010basis assessed the amount of respiratory symptoms and general illness in normal infants. In this population\u2010based birth cohort study, 228 healthy infants from Copenhagen, Denmark were followed from birth to 1 year of age during 2004\u20132006. Symptoms were registered using daily diaries and monthly home visits. Interviews were performed at inclusion and every second month. Risk factor analysis was carried out by multiple logistic regression analysis. On average, children had general symptoms for 3.5 months during their first year of life, nasal discharge being most frequent followed by cough. Frequency of all symptoms increased steeply after 6 months of age. Each child had on average 6.3 episodes (median: 5.1, inter\u2010quartile range (IQR): 3.3\u20137.8) of acute respiratory tract illness (ARTI) (nasal discharge and \u22651 of the following symptoms: cough, fever, wheezing, tachypnea, malaise, or lost appetite) and 5.6 episodes (median: 4.3, IQR: 2.1\u20137.3) of simple rhinitis per 365 days at risk. Determinants for respiratory symptoms were increasing age, winter season, household size, size of residence, day\u2010care attendance, and having siblings aged 1\u20133 years attending a day nursery. In conclusion, the present study provides detailed data on the occurrence of disease symptoms during the first year of life in a general population cohort and emphasizes the impact of increasing age, seasonality, and living conditions on the occurrence of ARTI. Pediatr Pulmonol. 2008; 43:584\u2013593. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20828","type":"journal-article","created":{"date-parts":[[2008,4,24]],"date-time":"2008-04-24T22:47:53Z","timestamp":1209077273000},"page":"584-593","source":"Crossref","is-referenced-by-count":68,"title":["Acute respiratory symptoms and general illness during the first year of life: A population\u2010based birth cohort study"],"prefix":"10.1002","volume":"43","author":[{"given":"Marie\u2010Louise","family":"von Linstow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus K\u00e4hler","family":"Holst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Kragh","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birthe","family":"H\u00f8gh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg143"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0373"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009540"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036050"},{"key":"e_1_2_1_6_2","first-page":"65","article-title":"Incidence and prevalence of non\u2010specific symptoms and behavioural changes in infants under the age of two years","volume":"45","author":"Holme CO","year":"1995","journal-title":"Br J Gen Pract"},{"key":"e_1_2_1_7_2","first-page":"880","article-title":"Everyday symptoms in childhood: Occurrence and general practitioner consultation rates","volume":"48","author":"Bruijnzeels MA","year":"1998","journal-title":"Br J Gen Pract"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/23.4.818"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0806.010321"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115243"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2007.01033.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20542"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531248"},{"key":"e_1_2_1_14_2","unstructured":"R Development Core Team R: A language and environment for statistical computinghttp:\/\/www.R\u2010project.org.2006."},{"key":"e_1_2_1_15_2","first-page":"12","article-title":"Yet another package for generalized estimating equations","volume":"2","author":"Geepack YanJ","year":"2002","journal-title":"R\u2010News"},{"key":"e_1_2_1_16_2","first-page":"5644","article-title":"Morbidity of Danish infants during their first months of life. 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