{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T17:24:20Z","timestamp":1774113860491,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,5,16]],"date-time":"2008-05-16T00:00:00Z","timestamp":1210896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Non\u2010atopic asthma is the predominant phenotype in non\u2010affluent parts of Latin America. We recently reported that infestation with <jats:italic>Ascaris lumbricoides<\/jats:italic> increased the risk of non\u2010atopic asthma in less affluent areas of Brazil but the mechanism is unclear. The present study was conducted to determine whether helminth infestation is associated with heightened bronchial responsiveness (BHR), a common finding in asthma. A random sample of 50 asthmatic and 50 non\u2010asthmatic controls (mean age 10.1 years) were selected from a larger cohort (n\u2009=\u20091,011) without knowledge of their helminth infestation status. Three stool samples were collected from each child on different days and each sample was analyzed by the Kato\u2010Katz method for quantitative determination of helminth eggs. Bronchial provocation tests were performed with inhaled 4.5% hypertonic saline using the ISAAC Phase II standardized protocol. There was no difference between the prevalence of positive BHR in the asthmatics (20.4%) compared with the controls (14.6%) (<jats:italic>P<\/jats:italic>\u2009=\u20091.0). Helminth infestation was detected in 24.0% of children, with <jats:italic>A. lumbricoides<\/jats:italic> being the most common. Children with high load infestation (\u2265100 eggs\/g) were five times more likely to have BHR than children with low load or no infestation. Despite the small sample size the results of the present study suggest that the link between high load helminth infestation and non\u2010atopic asthma may be mediated via heightened bronchial responsiveness, possibly due to an inflammatory response to the pulmonary phase of the helminth life cycle. Pediatr Pulmonol. 2008; 43:662\u2013665. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20833","type":"journal-article","created":{"date-parts":[[2008,5,16]],"date-time":"2008-05-16T23:16:20Z","timestamp":1210979780000},"page":"662-665","source":"Crossref","is-referenced-by-count":21,"title":["Intestinal helminth infestation is associated with increased bronchial responsiveness in children"],"prefix":"10.1002","volume":"43","author":[{"given":"Emerson R.","family":"da Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Sly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn U.","family":"de Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo A.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus H.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo M.","family":"Pitrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato T.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2004.01.007"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00127606"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200607-994OC"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1348"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.1.9606081"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200603-331OC"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2107020"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00090303"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.3.710"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01506.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00008004"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00623.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20485"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2002.01011.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000083401"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2005.05.006"}],"container-title":["Pediatric Pulmonology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fppul.20833","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ppul.20833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T23:29:14Z","timestamp":1697153354000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ppul.20833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1002\/ppul.20833"],"URL":"https:\/\/doi.org\/10.1002\/ppul.20833","archive":["Portico"],"relation":{},"ISSN":["8755-6863","1099-0496"],"issn-type":[{"value":"8755-6863","type":"print"},{"value":"1099-0496","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}