{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:02:27Z","timestamp":1761512547909},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,5,23]],"date-time":"2008-05-23T00:00:00Z","timestamp":1211500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>While aerosolized administration of \u03b2<jats:sub>2<\/jats:sub>\u2010adrenergic receptor (\u03b2<jats:sub>2<\/jats:sub>\u2010AR) agonists is the mainstay of treatment for pediatric asthma exacerbations, the efficacy of intravenous (IV) delivery is controversial. Failure to demonstrate improved outcomes with IV \u03b2<jats:sub>2<\/jats:sub>\u2010AR agonists may be due to phenotypic differences within this patient population. Our hypothesis is that children who respond more slowly to IV \u03b2<jats:sub>2<\/jats:sub>\u2010AR agonist therapy comprise a distinct phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective chart review of all children admitted to the ICU for status asthmaticus who were treated with IV terbutaline between December 2002 and September 2006.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010eight children were treated with IV terbutaline according to guidelines that adjusted the dose by clinical asthma score. After examining the histogram of duration of terbutaline infusions, a 48\u2010hr cutoff was chosen to define responsiveness. Thirty\u2010eight (49%) children were slow\u2010responders by this definition. There were no significant differences in baseline asthma severity or severity on admission between the slow\u2010responders and responders. Slow\u2010responders required significantly higher total doses of IV terbutaline, higher maximum administration rates, and had longer ICU and hospital length of stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were significant differences in outcomes between the responders and slow\u2010responders without differences in acute or chronic illness severity. Other factors may have lead to slower response to IV \u03b2<jats:sub>2<\/jats:sub>\u2010agonist therapy. Pediatr Pulmonol. 2008; 43:627\u2013633. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.20846","type":"journal-article","created":{"date-parts":[[2008,5,23]],"date-time":"2008-05-23T18:39:43Z","timestamp":1211567983000},"page":"627-633","source":"Crossref","is-referenced-by-count":9,"title":["Slow\u2010responders to IV \u03b2<sub>2<\/sub>\u2010adrenergic agonist therapy: Defining a novel phenotype in pediatric asthma"],"prefix":"10.1002","volume":"43","author":[{"given":"Christopher L.","family":"Carroll","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig M.","family":"Schramm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron R.","family":"Zucker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.6.1913"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(02)00033-0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8627(03)00054-3"},{"key":"e_1_2_1_5_2","first-page":"1145","article-title":"Acute asthma in the pediatric emergency department","volume":"46","author":"Smith SR","year":"1999","journal-title":"Emerg Med"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000154943.24151.58"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pec.0000278397.63246.33"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199810000-00033"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.4.1200"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20394"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60987-8"},{"key":"e_1_2_1_12_2","unstructured":"National Asthma Education and Prevention Program (NAEPP) Expert Panel: Guidelines for the Diagnosis and Management of Asthma\u2010Update on Selected Topics 2002. 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