{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:27:58Z","timestamp":1777602478349,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T00:00:00Z","timestamp":1240185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Preventing asthma exacerbation is an important goal of asthma management. The existing clinical tools are not good in predicting asthma exacerbations in young children. Childhood Asthma Control Test (C\u2010ACT) was recently published to be a simple tool for assessing disease control in young children. This study investigated C\u2010ACT and other disease\u2010related factors for indicating longitudinal changes in asthma status and predicting asthma exacerbations. During the same clinic visit, asthma patients aged 4\u201311 years completed the Chinese version of C\u2010ACT and underwent exhaled nitric oxide and spirometric measurements. Blinded to these results, the same investigator assigned Disease Severity Score (DSS) and rated asthma control according to Global Initiative for Asthma. Asthma exacerbations during the next 6 months were recorded. Ninety\u2010seven patients were recruited, with their mean (standard deviation [SD]) age being 9.2 (2.0) years. Thirty\u2010six (37.1%) patients had uncontrolled asthma at baseline. C\u2010ACT, DSS, and FEV\n                    <jats:sub>1<\/jats:sub>\n                    differed among patients with different control status (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001 for C\u2010ACT and DSS;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.028 for FEV\n                    <jats:sub>1<\/jats:sub>\n                    ). Thirty\u2010two patients had asthma exacerbations during the 6\u2010month follow\u2010up. Changes in patients' C\u2010ACT scores correlated with changes in asthma control status, DSS, and FEV\n                    <jats:sub>1<\/jats:sub>\n                    (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.019, 0.034, and 0.020, respectively). C\u2010ACT score was lower among patients with asthma exacerbations (mean [SD]: 22.9 [4.2] vs. 24.5 [2.1];\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.015). Logistic regression confirmed that the occurrence of asthma exacerbations was associated only with baseline C\u2010ACT (B\u2009=\u2009\u22120.203,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.042). In conclusion, C\u2010ACT is better than DSS and objective parameters in reflecting changes in asthma status and predicting asthma exacerbations in young children. Pediatr Pulmonol. 2009; 44:442\u2013449. \u00a9 2009 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ppul.20977","type":"journal-article","created":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T23:59:33Z","timestamp":1240271973000},"page":"442-449","source":"Crossref","is-referenced-by-count":15,"title":["Predicting changes in clinical status of young asthmatics: Clinical scores or objective parameters?"],"prefix":"10.1002","volume":"44","author":[{"given":"Ting F.","family":"Leung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny W.S.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary W.K.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung Y.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund","family":"Yung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.C.","family":"Hui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher K.W.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02064.x"},{"key":"e_1_2_1_3_2","unstructured":"Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention November 2006. 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