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MMP\u20109 and TIMP\u20101 levels in the cord blood were determined by ELISA. MMP\u20109\/TIMP\u20101 ratios in the cord blood of infants who developed severe or moderate BPD (n\u2009=\u20099) were significantly higher than those who developed mild BPD or did not develop BPD (n\u2009=\u200920; <jats:italic>P<\/jats:italic>\u2009=\u20090.015). Multivariate linear regressions demonstrated that MMP\u20109 levels and MMP\u20109\/TIMP\u20101 ratios in the cord blood of the premature infants correlated with the oxygen supplementation period (r\u2009=\u20090.58, <jats:italic>P<\/jats:italic>\u2009=\u20090.003 and r\u2009=\u20090.41, <jats:italic>P<\/jats:italic>\u2009=\u20090.030, respectively). The MMP\u20109 levels and MMP\u20109\/TIMP\u20101 ratios correlated with the severity of maternal chorioamnionitis (both trend <jats:italic>P<\/jats:italic>\u2009=\u20090.006).<\/jats:p><jats:p>The MMP\u20109 levels and MMP\u20109\/TIMP\u20101 ratios in the cord blood may be related to the pathogenesis and severity of BPD and maternal chorioamnionitis. Pediatr Pulmonol. 2009; 44:267\u2013272. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.20993","type":"journal-article","created":{"date-parts":[[2009,2,9]],"date-time":"2009-02-09T20:26:07Z","timestamp":1234211167000},"page":"267-272","source":"Crossref","is-referenced-by-count":24,"title":["MMP\u20109 and TIMP\u20101 in the cord blood of premature infants developing BPD"],"prefix":"10.1002","volume":"44","author":[{"given":"Shinnosuke","family":"Fukunaga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ichiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Maeba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Nakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiro","family":"Sugino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196702162760701"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.215"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.113321"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70276-X"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(96)00179-8"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026028303196"},{"key":"e_1_2_1_8_2","first-page":"151","article-title":"Activation mechanisms of matrix metalloproteinases","volume":"378","author":"Nagase H","year":"1997","journal-title":"Biol Chem"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(97)90025-1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118286"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.6.1709"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000047063"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb03020.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1542\/peds.79.1.26","article-title":"Is chronic lung disease in low birth weight infants preventable? 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