{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:43:36Z","timestamp":1754109816779},"reference-count":67,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T00:00:00Z","timestamp":1240185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2009,5]]},"abstract":"Abstract<\/jats:title>The value of exercise testing as an objective measure of disease severity in patients with chronic chest diseases (CCD) is becoming increasingly recognized. The aim of this study was to investigate changes in oxygen uptake $({\\buildrel {.} \\over {\\rm V}}{\\rm O}_2)$<\/jats:styled-content> during early recovery following maximal cardiopulmonary exercise testing (CPXT) in relation to functional capacity and markers of disease severity. Twenty\u2010seven children with CCD (age 12.7\u2009\u00b1\u20093.1 years; 17 female) [19 children with Cystic fibrosis (CF) (age 13.4\u2009\u00b1\u20093.1 years; 10 female) and 8 with other stable non\u2010CF chest diseases (NON\u2010CF) (age 11.1\u2009\u00b1\u20092.2 years; 7 female)] and 27 healthy controls (age 13.2\u2009\u00b1\u20093.3 years; 17 female) underwent CPXT on a cycle ergometer. On\u2010line respiratory gas analysis measured $({\\buildrel {.} \\over {\\rm V}}{\\rm O}_2)$<\/jats:styled-content> before and during CPXT to peak $({\\buildrel {.} \\over {\\rm V}}{\\rm O}_2)$<\/jats:styled-content> $({\\buildrel {.} \\over {\\rm V}}{\\rm O}_2)$<\/jats:styled-content>peak<\/jats:sub>, and during the first 10 min of recovery. Early $({\\buildrel {.} \\over {\\rm V}}{\\rm O}_2)$<\/jats:styled-content> recovery was quantified by the time (sec) to reach 50% of the $({\\buildrel {.} \\over {\\rm V}}{\\rm O}_2)$<\/jats:styled-content> peak<\/jats:sub> value. Early $({\\buildrel {.} \\over {\\rm V}}{\\rm O}_2)$<\/jats:styled-content> recovery was correlated against spirometry [forced expiratory volume in 1 sec (FEV1<\/jats:sub>) and forced expiratory flow between 25% and 75% of the forced vital capacity (FEF25\u201375<\/jats:sub>)] and aerobic fitness $({\\buildrel {.} \\over {\\rm V}}{\\rm O}_2)$<\/jats:styled-content>peak<\/jats:sub> as a measure of functional capacity. Disease severity was graded in the CF patients by the Shwachman score (SS). Compared to controls, children with CCD demonstrated a significantly reduced $({\\buildrel {.} \\over {\\rm V}}{\\rm O}_2)$<\/jats:styled-content>peak<\/jats:sub> (P<\/jats:italic>\u2009=\u20090.011), FEV1<\/jats:sub> (P<\/jats:italic>\u2009<\u20090.001), FEF25\u201375<\/jats:sub> (P<\/jats:italic>\u2009<\u20090.001), and a significantly prolonged early $({\\buildrel {.} \\over {\\rm V}}{\\rm O}_2)$<\/jats:styled-content> recovery (P<\/jats:italic>\u2009=\u20090.024). In the CF patients the SS was significantly correlated with early $({\\buildrel {.} \\over {\\rm V}}{\\rm O}_2)$<\/jats:styled-content> recovery (r\u2009=\u2009\u22120.63, P<\/jats:italic>\u2009=\u20090.004), FEV1<\/jats:sub> (r\u2009=\u20090.72, P<\/jats:italic>\u2009=\u20090.001), and FEF25\u201375<\/jats:sub> (r\u2009=\u20090.57, P<\/jats:italic>\u2009=\u20090.011). In the children with CCD, FEV1<\/jats:sub>, FEF25\u201375<\/jats:sub>, and BMI were not significantly correlated with $({\\buildrel {.} \\over {\\rm V}}{\\rm O}_2)$<\/jats:styled-content>peak<\/jats:sub> or early $({\\buildrel {.} \\over {\\rm V}}{\\rm O}_2)$<\/jats:styled-content> recovery. Lung function does not necessarily reflect aerobic fitness and the ability to recover from exercise in these patients. A significant relationship was found between $({\\buildrel {.} \\over {\\rm V}}{\\rm O}_2)$<\/jats:styled-content>peak<\/jats:sub> and early $({\\buildrel {.} \\over {\\rm V}}{\\rm O}_2)$<\/jats:styled-content> recovery (r\u2009=\u2009\u22120.39, P<\/jats:italic>\u2009=\u20090.044) in the children with CCD, showing that a greater aerobic fitness corresponded with a faster recovery. Pediatr Pulmonol. 2009; 44:480\u2013488. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.21024","type":"journal-article","created":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T03:59:33Z","timestamp":1240286373000},"page":"480-488","source":"Crossref","is-referenced-by-count":18,"title":["Early oxygen uptake recovery following exercise testing in children with chronic chest diseases"],"prefix":"10.1002","volume":"44","author":[{"given":"D.","family":"Stevens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J.","family":"Oades","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00046906"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1986.133.1.14"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02723157"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00142903"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204303261804"},{"key":"e_1_2_1_7_2","first-page":"30","article-title":"Exercise and cystic fibrosis","volume":"88","author":"Webb AK","year":"1995","journal-title":"J R Soc Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(199804)25:4<223::AID-PPUL1>3.0.CO;2-L"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.4.9705023"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212173272504"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.95.2.344"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.008102"},{"key":"e_1_2_1_13_2","first-page":"286","article-title":"Exercise testing and training with the young Cystic fibrosis patient","volume":"6","author":"Stevens D","year":"2007","journal-title":"J Sports Sci Med"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.86.1.135"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1988.254.4.C548"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00585149"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365517909108833"},{"key":"e_1_2_1_18_2","first-page":"77","article-title":"Bioenergetics of intact human muscle. 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