{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T17:45:47Z","timestamp":1774115147442,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Increased intrathoracic pressures during airway pressure release ventilation (APRV) may compromise systemic venous return resulting in decreased cardiac output and renal perfusion. We sought to study the short\u2010term effect of APRV on blood pressure (BP) and urine output (UO) in children with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>All patients with ALI\/ARDS who were admitted to our Pediatric Intensive Care Unit (PICU) between 1\/00 and 06\/04, and who were ventilated with APRV (for at least 12\u2009hr) for worsening oxygenation while on conventional ventilation (CV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Results<\/jats:title><jats:p>Medical records were reviewed for patients' demographics, Pediatric Risk of Mortality (PRISM III) score, admitting diagnosis, ventilator settings, gas exchange data, heart rate (HR), central venous pressure (CVP), blood pressure (BP), UO, and use of other therapies [sedatives, pressors, inotropes, and intravenous fluid (IVF)]. Eleven patients met our inclusion and exclusion criteria with a mean age of 6.2\u2009\u00b1\u20094.8 years (range: 1\u201315 years), a weight of 35.5\u2009\u00b1\u200929.5\u2009kg (range: 12\u201390\u2009kg), and a PRISM score of 18.4\u2009\u00b1\u20099.6 (range: 2\u201336). Within 10\u2009hrs of APRV, patients' mean airway pressure (Paw) increased from 16.1\u2009\u00b1\u20096.6 to 21.1\u2009\u00b1\u20095.5\u2009cm of H<jats:sub>2<\/jats:sub>O (<jats:italic>P<\/jats:italic>\u2009=\u20090.04). Despite a higher Paw there were no differences in HR, CVP, BP, UO, IVF and use of other therapies while on CV or APRV (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.10).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In children with ALI\/ARDS, despite a higher Paw, APRV does not affect BP or UO. Pediatr Pulmonol. 2010; 45:48\u201354. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ppul.21058","type":"journal-article","created":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T22:13:45Z","timestamp":1259705625000},"page":"48-54","source":"Crossref","is-referenced-by-count":18,"title":["Effects of airway pressure release ventilation on blood pressure and urine output in children"],"prefix":"10.1002","volume":"45","author":[{"given":"Sameer S.","family":"Kamath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis M.","family":"Super","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maroun J.","family":"Mhanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.3.7509706"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107042"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198402000-00011"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198302000-00002"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198305000-00008"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198705000-00001"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421801"},{"key":"e_1_2_1_9_2","first-page":"372","article-title":"Open up the lung and keep the lung open","volume":"16","author":"Lachmann B","year":"1990","journal-title":"Intensive Care Med"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802053380602"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.1.54"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032193"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052052"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00044067-200105000-00007"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000155920.11893.37"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199110000-00004"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.94.4.779"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.6.8004312"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200507000-00010"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.2.460"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.1.2001078"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00130478-200107000-00010"},{"key":"e_1_2_1_23_2","first-page":"1019","article-title":"Airway Pressure Release Ventilation with short release time in a child with Acute Respiratory Distress Syndrome","volume":"46","author":"Foland JA","year":"2001","journal-title":"Respir Care"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20550"},{"key":"e_1_2_1_25_2","first-page":"842","article-title":"Airway pressure release ventilation for a pediatric patient on extracorporeal membrane oxygenation: a case study (abstract). 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