{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T06:58:26Z","timestamp":1769237906044,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bronchiectasis (BE) is still an important cause of chronic supurative respiratory diseases in developing countries. Neutrophil\u2010derived proteases such as neutrophil elastase and matrix metalloproteases (MMPs) are implicated in causing airway damage in chronic pulmonary disease. In this study, we aimed to evaluate the MMP\u20109 and its natural tissue inhibitors of metalloproteinases (TIMP\u20101) levels utilizing the exhaled breath condensate (EBC) method and their relationship with radiological findings and pulmonary functions in children with BE.<\/jats:p><jats:p>Thirty\u2010eight children with BE and 12 healthy children were included: Group 1 (cystic fibrosis [CF] BE), Group 2 (non\u2010CF BE), Group 3 (control group). High\u2010resolution computerized tomography (HRCT) scores were calculated according to the anatomic extent of BE. Pulmonary function tests were performed, and MMP\u20109 and TIMP\u20101 levels in EBC were analyzed by ELISA.<\/jats:p><jats:p>Exhaled breath condensate MMP\u20109 level was 48.9\u2009\u00b1\u200926.8\u2009ng\/ml for Group 1, and for Group 2, 42.8\u2009\u00b1\u200918.1\u2009ng\/ml; and for Group 3, 30\u2009\u00b1\u20093.7\u2009ng\/ml. Although no statistically significant difference was found between the Groups 1 and 2, a significant difference was detected between these groups and controls. No statistically significant difference was found in TIMP\u20101 levels regarding all groups. EBC MMP\u20109 levels were inversely correlated with pulmonary functions test, and positively with HRCT scores and annual number of pulmonary infections.<\/jats:p><jats:p>In conclusion, this study showed that EBC of children with both CF BE and non\u2010CF BE contained higher levels of MMP\u20109 in comparison to controls. We suggest that EBC MMP\u20109 level may be a useful marker of airway injury in patients with BE however prospective studies are needed. Pediatr Pulmonol. 2009; 44:1010\u20131016. \u00a92009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ppul.21096","type":"journal-article","created":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T18:05:23Z","timestamp":1251828323000},"page":"1010-1016","source":"Crossref","is-referenced-by-count":28,"title":["Exhaled breath condensate MMP\u20109 levels in children with bronchiectasis"],"prefix":"10.1002","volume":"44","author":[{"given":"Gulbin Bingol","family":"Karakoc","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayfer","family":"Inal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya Ufuk","family":"Altintas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seval Guneser","family":"Kendirli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7216-3695-5.50033-X"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/prrv.2000.0011"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/137.4.969"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1104"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000085362"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmi036"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2003.00101.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0496(200003)29:3<182::AID-PPUL5>3.0.CO;2-T"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10289"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.11.007"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20587"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.011577"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.9.2105083"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00282402"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.2.420"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.39.6.408"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01489487"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.5.9907064"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.849"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10122788"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00029705"},{"key":"e_1_2_1_23_2","unstructured":"Global Initiative for Asthma.Global Strategy for Asthma Management and Prevention. 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