{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:17Z","timestamp":1786978337197,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,9,10]],"date-time":"2009-09-10T00:00:00Z","timestamp":1252540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was designed to assess the hypothesis that leukotriene receptor antagonists (LTRAs) would provide additional symptom relief in asthmatic children with persistent AR already taking regular antihistamine. The effects of 16\u2010week treatment of LTRA in addition to fexofenadine (FEX) on persistent AR in asthmatic children were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Consecutive children with stable asthma and persistent AR were invited in this randomized, double\u2010blind, placebo\u2010controlled study. After a 2\u2010week run\u2010in period in which subjects were given FEX alone, they were randomly assigned to take LTRA or placebo in addition to FEX for 16 weeks, followed by 8 weeks of follow\u2010up phase with FEX taken alone. Symptom scoring, rhinoscopy, acoustic rhinometry, spirometry, nasal secretion extraction and blood taking for IL\u20104 and IL\u201013 analysis were performed after a 2\u2010week run\u2010in and at the end of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010four subjects with a median (IQR) age of 12.2 (10.1\u201314.1) years were recruited. At week 4 of treatment, the between\u2010group differences in the mean changes of daytime sneezing score (mean difference (95% CI)\u2009=\u2009\u22120.35 (\u22120.59, \u22120.12),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004), nighttime sneezing score (mean difference (95% CI)\u2009=\u2009\u22120.37 (\u22120.62, \u22120.11),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.007) and daytime composite score (mean difference (95% CI)\u2009=\u2009\u22121.08 (\u22121.92, \u22120.25),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.013) were significant. Acoustic rhinometry also demonstrated a nearly significant difference in nasal volume change between groups at 16 weeks of treatment (mean difference (95% CI)\u2009=\u20090.572 (0.090\u20131.054),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.021). IL\u20104 and IL\u201013 were not detected in the majority of nasal secretion or serum samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Additional LTRA provided a more rapid relief on sneezing at the 4\u2010week time point. This combination therapy also maintained a greater nasal volume and this might translate to lesser nasal congestion. Pediatr Pulmonol. 2009; 44:1085\u20131092. \u00a92009 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ppul.21102","type":"journal-article","created":{"date-parts":[[2009,9,10]],"date-time":"2009-09-10T13:30:30Z","timestamp":1252589430000},"page":"1085-1092","source":"Crossref","is-referenced-by-count":30,"title":["Leukotriene receptor antagonist in the treatment of childhood allergic rhinitis\u2014a randomized placebo\u2010controlled study"],"prefix":"10.1002","volume":"44","author":[{"given":"Albert M.","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor J.","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chui S.","family":"Tsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun 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