{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:40:05Z","timestamp":1787244005692,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Pulmonology"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The objective of this study was to investigate the effectivenesses of nebulized salbutamol, epinephrin, 3% saline, and normal saline (0.9% NaCl) in the treatment of mildly affected infants with acute bronchiolitis. We enrolled 186 children (mean age 9.5\u2009\u00b1\u20095.3 months, range 1.5\u201324 months, 65.1% male) with a first episode of wheezing diagnosed as mild bronchiolitis in emergency department. Patients were randomized in a double\u2010blind fashion to receive 4\u2009ml dose either of 1.5\u2009mg epinephrine plus normal saline (group 1; n\u2009=\u200938) or 1.5\u2009mg epinephrine plus 3% saline (group 2; n\u2009=\u200939) or 2.5\u2009mg salbutamol plus normal saline (group 3; n\u2009=\u200936) or 2.5\u2009mg salbutamol plus 3% saline (group 4; n\u2009=\u200936) or normal saline alone (group 5; n\u2009=\u200937) at 0 and 30\u2009min. Thus, all treatment modalities included high amount of NaCl (72\u2013240\u2009mg). Clinical score, oxygen saturation and heart rate were assessed at 0, 30, 60, and 120\u2009min. After discharge, patients were reassessed by telephone contact at 48\u2009hr and 6 months. The baseline characteristics were similar in all groups (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&gt;\u20090.05). The outcome of patients at 120\u2009min was found significantly better than the baseline values (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). There were no significant differences between the outcome variables of the groups (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&gt;\u20090.05). No adverse effects attributable to nebulized therapy were seen. In conclusion, all treatment modalities used in this study, including a total of 8\u2009ml normal saline inhalation at 30\u2010min interval showed clinically significant and swift improvement in mildly affected ambulatory infants with acute bronchiolitis. Pediatr Pulmonol. 2010; 45:41\u201347. \u00a9 2009 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ppul.21108","type":"journal-article","created":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T17:13:11Z","timestamp":1259687591000},"page":"41-47","source":"Crossref","is-referenced-by-count":66,"title":["High volume normal saline alone is as effective as nebulized salbutamol\u2010normal saline, epinephrine\u2010normal saline, and 3% saline in mild bronchiolitis"],"prefix":"10.1002","volume":"45","author":[{"given":"Ayse Berna","family":"Anil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Anil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse 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